Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nizatidine
Drug ID BADD_D01582
Description A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA04
DrugBank ID DB00585
KEGG ID D00440
MeSH ID D016567
PubChem ID 3033637
TTD Drug ID D0Q9DK
NDC Product Code 55111-310; 55111-311; 60846-301; 68071-1633; 63629-2769; 68462-425; 71335-0086; 63187-249; 0591-3137; 68071-5043; 65162-659; 0591-3138; 55111-011; 72643-018; 68462-426
Synonyms Nizatidine | N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine | LY-139037 | LY 139037 | LY139037 | Axid
Chemical Information
Molecular Formula C12H21N5O2S2
CAS Registry Number 76963-41-2
SMILES CNC(=C[N+](=O)[O-])NCCSCC1=CSC(=N1)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vasculitis24.05.02.001; 10.02.02.006--
Ventricular tachycardia02.03.04.010--
Vomiting07.01.07.003--
Musculoskeletal discomfort15.03.04.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Liver injury12.01.02.003; 09.01.07.022--Not Available
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