Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitrous oxide
Drug ID BADD_D01580
Description Nitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug.
Indications and Usage
Marketing Status Prescription
ATC Code N01AX13
DrugBank ID DB06690
KEGG ID D00102
MeSH ID D009609
PubChem ID 948
TTD Drug ID D0O8DI
NDC Product Code 62273-005; 72223-001; 21220-122; 55037-301; 44517-020; 70151-004; 25373-703; 59579-004; 49575-003; 46123-007; 63978-201; 46362-003; 55050-0018; 46123-006; 18482-002; 44076-012; 48273-002; 54260-001; 20703-003; 10736-017; 10014-003; 10167-200; 10252-003; 52086-003; 62045-8333; 43621-003; 12213-593; 72276-002; 55404-002; 24312-003; 62097-0004; 51486-007; 52568-002; 12121-002; 73468-004; 72343-001; 42602-003; 34057-010; 53440-003; 11054-007; 25373-103; 67525-400; 54218-800; 67477-002; 17575-011; 52346-012; 25373-003; 50554-005; 53511-003
Synonyms Nitrous Oxide | Oxide, Nitrous | Laughing Gas | Gas, Laughing | Nitrogen Protoxide
Chemical Information
Molecular Formula N2O
CAS Registry Number 10024-97-2
SMILES [N-]=[N+]=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myelopathy17.10.01.0070.002364%Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.0010.000788%Not Available
Neuropathy peripheral17.09.03.0030.001970%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.000788%Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.0050.001970%
Polyneuropathy17.09.03.0120.002364%Not Available
Pregnancy18.08.02.004--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.000788%Not Available
Radiculopathy17.10.01.0050.000788%
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Subcutaneous emphysema23.07.04.006; 12.02.06.0020.000788%
Thrombocytopenia01.08.01.002--Not Available
Vitamin B12 decreased13.02.05.0020.001576%Not Available
Vitamin B12 deficiency14.12.02.0040.007093%Not Available
Vomiting07.01.07.003--
Pneumomediastinum22.09.03.0040.001576%Not Available
Peripheral sensorimotor neuropathy17.09.03.0090.000788%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.000788%
Metabolic disorder14.11.01.0010.000788%Not Available
Central nervous system stimulation25.04.01.001--Not Available
Demyelinating polyneuropathy17.09.04.003; 10.04.10.0070.000788%Not Available
Psychotic disorder19.03.01.0020.000788%
Amino acid level increased13.09.01.0170.001576%Not Available
Bone marrow failure01.03.03.005--
Substance abuse19.07.02.0060.002364%Not Available
Vascular resistance pulmonary increased13.14.03.020--Not Available
Occupational exposure to product12.03.06.001--Not Available
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