Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Moxifloxacin
Drug ID BADD_D01501
Description Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Indications and Usage For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
Marketing Status Prescription; Discontinued
ATC Code J01MA14; S01AE07
DrugBank ID DB00218
KEGG ID D08237
MeSH ID D000077266
PubChem ID 152946
TTD Drug ID D0ZV0Z
NDC Product Code 50090-3147; 0904-6406; 0378-5430; 65977-0038; 12527-0517; 17478-519; 72189-334; 72789-233; 50090-5279; 60505-0582; 67296-1679; 65862-840; 61919-553; 68180-422; 68180-421; 63629-8357; 72189-321; 72189-076; 55111-112
Synonyms Moxifloxacin | 1-Cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | Octegra | Proflox | Moxifloxacin Hydrochloride | Avelox | Avalox | Izilox | Actira | BAY 12-8039 | BAY 12 8039 | BAY-12-8039 | BAY 128039 | BAY-128039 | BAY128039
Chemical Information
Molecular Formula C21H24FN3O4
CAS Registry Number 151096-09-2
SMILES COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Corneal neovascularisation24.03.07.009; 06.07.01.0030.000578%Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hepatic enzyme increased13.03.01.019--Not Available
Calcium ionised increased13.11.01.018--Not Available
Oral fungal infection11.03.05.010; 07.05.07.009--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Psychotic disorder19.03.01.002--
Hyperlipidaemia14.08.03.001--
Renal impairment20.01.03.010--Not Available
Self injurious behaviour19.12.01.005--Not Available
Infusion site extravasation12.07.05.008; 08.02.05.007--
Vulvovaginal mycotic infection11.03.05.004; 21.14.02.004--Not Available
Ulcerative keratitis06.04.02.004; 10.02.01.0210.003470%
Ventricular tachyarrhythmia02.03.04.012--Not Available
Suicidal behaviour19.12.01.006--Not Available
Acute kidney injury20.01.03.016--
Bilirubin conjugated decreased13.03.01.039--Not Available
Candida infection11.03.03.021--
Eye infection staphylococcal11.02.05.012; 06.04.05.0260.000578%Not Available
Anterior chamber disorder06.06.07.0020.001157%Not Available
Keratitis fungal11.03.05.023; 06.04.02.0120.000868%Not Available
Toxic anterior segment syndrome12.02.02.010; 06.04.10.0060.003181%Not Available
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