Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Morphine
Drug ID BADD_D01498
Description Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.[L12114]
Indications and Usage For the relief and treatment of severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AA01
DrugBank ID DB00295
KEGG ID D08233
MeSH ID D009020
PubChem ID 5288826
TTD Drug ID D0WE3O
NDC Product Code 42799-217
Synonyms Morphine | Morphia | Morphine Chloride | Chloride, Morphine | Morphine Sulfate | Sulfate, Morphine | SDZ 202-250 | SDZ 202 250 | SDZ 202250 | SDZ202-250 | SDZ202 250 | SDZ202250 | Morphine Sulfate (2:1), Pentahydrate | MS Contin | Contin, MS | Oramorph SR | Duramorph | Morphine Sulfate (2:1), Anhydrous
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 57-27-2
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cardiac arrhythmiasMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
Cardiac arrhythmiasMu-type opioid receptorP35372T4776825806604
HyperpathiaProtein kinase C alpha typeP17252T1280825806604
HyperpathiaMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
HyperpathiaTranscription factor JunP05412T6908525806604
HyperpathiaMu-type opioid receptorP35372T4776825806604
HyperpathiaMitogen-activated protein kinase 8P45983T4009725806604
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.0020.007263%
Ear pain04.03.01.003--
Eating disorder14.03.01.008; 19.09.01.008--Not Available
Ejaculation disorder21.03.01.002--
Electrocardiogram QT prolonged13.14.05.004--
Electroencephalogram abnormal13.07.03.0010.000703%Not Available
Electrolyte imbalance14.05.01.0020.000937%Not Available
Emotional disorder19.04.02.005--Not Available
Encephalitis11.01.03.008; 17.06.05.0010.000122%
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.0010.000244%
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Eye pain06.08.03.002--
Face oedema23.04.01.004; 08.01.07.003; 10.01.05.002--
Fatigue08.01.01.002--
Fear19.06.03.001--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.0140.012886%Not Available
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.016--Not Available
Flat affect19.04.01.004--Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Formication19.10.02.010; 17.02.06.0180.000703%Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
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