Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Molindone hydrochloride
Drug ID BADD_D01488
Description An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Indications and Usage Molindone is used for the management of the manifestations of psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AE02
DrugBank ID DB01618
KEGG ID D00796
MeSH ID D008972
PubChem ID 9883259
TTD Drug ID D03AJF
NDC Product Code 42806-337; 14096-126; 42973-126; 42806-338; 42806-336
Synonyms Molindone | Moban | Molindone Hydrochloride | Hydrochloride, Molindone | Molindone Monohydrochloride | Monohydrochloride, Molindone
Chemical Information
Molecular Formula C16H25ClN2O2
CAS Registry Number 15622-65-8
SMILES CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Akathisia19.06.02.006; 17.01.02.002--
Amenorrhoea21.01.02.001; 05.05.01.002--
Blood glucose abnormal13.02.02.008--Not Available
Blood urea abnormal13.13.01.005--Not Available
Constipation07.02.02.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dry mouth07.06.01.002--
Dystonia17.01.03.001--Not Available
Euphoric mood19.04.02.006--
Extrapyramidal disorder17.01.02.007--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gynaecomastia05.05.02.003; 21.05.04.003--
Hepatic function abnormal09.01.02.001--Not Available
Hypotension24.06.03.002--
Lenticular opacities06.06.01.003--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido increased21.03.02.007; 19.08.03.002--
Menstruation irregular21.01.01.005; 05.05.01.008--
Nausea07.01.07.001--
Parkinsonism17.01.05.003--Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Tardive dyskinesia17.01.02.012--Not Available
Thyroid function test abnormal13.10.06.001--Not Available
Urinary retention20.02.02.011--
Vision blurred17.17.01.010; 06.02.06.007--
The 1th Page    1 2    Next   Last    Total 2 Pages