Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline
Drug ID BADD_D01470
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D05045
MeSH ID D008911
PubChem ID 54675783
TTD Drug ID D08LTU
NDC Product Code 42291-591; 42291-589; 69489-201; 72356-101; 49884-512; 72356-103; 63629-2228; 49884-513; 63629-2229; 49884-511
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H27N3O7
CAS Registry Number 10118-90-8
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not Available1421660; 3224399; 1814842
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.0010.005696%
Eosinophilic myocarditis02.04.03.002; 01.02.04.0070.001959%Not Available
Eosinophilic pneumonia01.02.04.003; 22.01.01.0040.001812%Not Available
Epididymitis21.09.02.001; 11.01.19.0050.000518%Not Available
Erythema23.03.06.0010.002330%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000518%
Erythema nodosum23.07.02.001; 10.02.01.0200.001294%Not Available
Eye pain06.08.03.0020.000518%
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000518%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.0020.000518%Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.002330%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Fixed drug eruption08.01.06.017; 23.03.05.006; 10.01.01.0220.001036%Not Available
Fontanelle bulging18.04.04.001; 17.02.05.006--Not Available
Fungaemia11.01.11.0020.000203%
Gait disturbance17.02.05.016; 08.01.02.0020.003107%
Gamma-glutamyltransferase increased13.03.01.0110.000518%
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.000777%
Gingival discolouration07.09.11.002--Not Available
Glossitis07.14.01.001--Not Available
Goitre14.11.01.008; 05.02.01.0010.001036%Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.0010.011132%
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000518%Not Available
Hepatic failure09.01.03.0020.000338%
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