Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mexiletine hydrochloride
Drug ID BADD_D01453
Description Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Indications and Usage For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Marketing Status Prescription; Discontinued
ATC Code C01BB02
DrugBank ID DB00379
KEGG ID D00639
MeSH ID D008801
PubChem ID 21467
TTD Drug ID D0X0RI
NDC Product Code 42291-625; 46708-871; 62559-820; 0527-4107; 63629-1963; 63629-2145; 10135-731; 63629-1964; 17511-136; 0527-4109; 62559-822; 0093-8740; 51407-380; 63629-9179; 51407-381; 0093-8741; 51407-379; 0527-4108; 42291-626; 62756-956; 65977-0122; 10135-730; 63629-9180; 51927-2953; 50742-239; 42291-624; 62559-821; 0093-8739; 62756-955; 73435-007; 53296-0029; 10135-732; 63629-9181; 62756-957; 50742-241; 72166-007; 50742-240
Synonyms Mexiletine | Novo-Mexiletine | Novo Mexiletine | Mexiletine Hydrochloride | Mexitil | Mexitil PL | Mexityl | KO-1173 | KO 1173 | KO1173 | KOE-1173 | KOE 1173 | KOE1173 | Mexiletene
Chemical Information
Molecular Formula C11H18ClNO
CAS Registry Number 5370-01-4
SMILES CC1=C(C(=CC=C1)C)OCC(C)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Toxicity to various agentsCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Mucous membrane disorder08.01.06.004--Not Available
Myelofibrosis16.21.03.001; 01.13.03.005--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema08.01.07.006; 14.05.06.010--Not Available
Oesophageal ulcer07.04.05.002--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
Pulmonary fibrosis22.01.02.006--
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