Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Metyrapone
Drug ID BADD_D01450
Description An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Indications and Usage Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.
Marketing Status approved; investigational
ATC Code V04CD01
DrugBank ID DB01011
KEGG ID D00410
MeSH ID D008797
PubChem ID 4174
TTD Drug ID D0Q9JT
NDC Product Code 70219-0001; 55361-0011; 76336-455
UNII ZS9KD92H6V
Synonyms Metyrapone | Methbipyranone | Methopyrapone | SU 4885 | Metopirone | Métopirone | Metopiron
Chemical Information
Molecular Formula C14H14N2O
CAS Registry Number 54-36-4
SMILES CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abortion spontaneous18.01.04.0010.000099%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000148%
Adrenocortical insufficiency acute14.11.01.020; 05.01.02.0050.000099%Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.0010.000099%
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.0010.000099%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dysphagia07.01.06.0030.000099%
Dyspnoea02.11.05.003; 22.02.01.0040.000099%
Endocrine disorder05.09.01.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hirsutism23.02.04.001; 05.05.01.005--
Hypercalcaemia05.04.01.002; 14.04.01.0030.000099%
Hypertension24.08.02.001--
Hypotension24.06.03.0020.000198%
Malaise08.01.01.0030.000217%
Nausea07.01.07.0010.000099%
Nervous system disorder17.02.10.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.000099%
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Premature baby18.04.02.0010.000099%Not Available
Premature delivery18.07.01.0060.000099%
Pulmonary embolism24.01.06.001; 22.06.02.0010.000148%Not Available
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