Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metyrapone
Drug ID BADD_D01450
Description An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Indications and Usage Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.
Marketing Status Prescription; Discontinued
ATC Code V04CD01
DrugBank ID DB01011
KEGG ID D00410
MeSH ID D008797
PubChem ID 4174
TTD Drug ID D0Q9JT
NDC Product Code 70219-0001; 55361-0011; 76336-455
Synonyms Metyrapone | Methbipyranone | Methopyrapone | SU 4885 | Metopirone | Métopirone | Metopiron
Chemical Information
Molecular Formula C14H14N2O
CAS Registry Number 54-36-4
SMILES CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abortion spontaneous18.01.04.0010.000388%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000582%
Adrenocortical insufficiency acute14.11.01.020; 05.01.02.0050.000388%Not Available
Alopecia23.02.02.001--
Cellulitis23.09.01.001; 11.02.01.0010.000582%Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.0010.000388%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.0020.000388%
Endocrine disorder05.09.01.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hirsutism05.05.01.005; 23.02.04.001--
Hypertension24.08.02.001--
Hypotension24.06.03.0020.000776%
Nausea07.01.07.0010.000388%
Nervous system disorder17.02.10.001--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Pneumonia cytomegaloviral22.07.05.001; 11.05.01.0010.000388%Not Available
Premature baby18.04.02.0010.000582%Not Available
Premature delivery18.07.01.0060.000388%
Pulmonary embolism24.01.06.001; 22.06.02.0010.000582%Not Available
Renal failure20.01.03.0050.000388%Not Available
Respiratory arrest22.02.01.0090.000388%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000101%
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