Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Marketing Status Prescription; Discontinued
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 70165-200; 68968-5554; 0406-7654; 0781-2361; 0781-2364; 68968-5553; 68968-5555; 70165-100; 70165-300; 68968-5552; 0781-2363; 0781-2362
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityBeta-2 adrenergic receptorP07550T525229187524; 7913199; 8382844; 6147001; 1957308; 7716792; 12616289
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.002--
Fear19.06.03.0010.000918%Not Available
Feeling abnormal08.01.09.0140.006702%Not Available
Feeling cold08.01.09.0080.000184%Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.0160.001285%Not Available
Feeling of despair19.15.02.0060.000275%Not Available
Feeling of relaxation08.01.09.0170.000184%Not Available
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.017--Not Available
Flat affect19.04.01.004--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Foetal distress syndrome18.03.02.0030.000184%Not Available
Food allergy10.01.01.0120.000275%Not Available
Foot fracture15.08.03.012; 12.04.01.0120.000184%Not Available
Formication19.10.02.010; 17.02.06.0180.001102%Not Available
Fracture15.08.02.001; 12.04.02.0010.001469%
Fungal infection11.03.05.001--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gastric cancer16.13.03.001; 07.21.02.0010.000048%Not Available
Gastritis07.08.02.001--
Gastroenteritis11.01.07.004; 07.19.03.0010.000275%Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.0050.000184%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised anxiety disorder19.06.01.0040.000184%Not Available
Generalised tonic-clonic seizure17.12.01.0020.000551%Not Available
Gingival disorder07.09.03.0010.000184%Not Available
Gingival recession07.09.03.0070.000275%Not Available
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