Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Marketing Status Prescription; Discontinued
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 70165-200; 68968-5554; 0406-7654; 0781-2361; 0781-2364; 68968-5553; 68968-5555; 70165-100; 70165-300; 68968-5552; 0781-2363; 0781-2362
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityBeta-2 adrenergic receptorP07550T525229187524; 7913199; 8382844; 6147001; 1957308; 7716792; 12616289
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eczema23.03.04.0060.000275%
Electrocardiogram abnormal13.14.05.0010.000367%Not Available
Electrocardiogram QRS complex prolonged13.14.05.0030.000184%Not Available
Electrocardiogram QT prolonged13.14.05.0040.002663%
Electrocardiogram ST segment elevation13.14.05.0250.000551%Not Available
Electrocardiogram T wave inversion13.14.05.0070.000459%Not Available
Emotional disorder19.04.02.0050.002571%Not Available
Encephalitis17.06.05.001; 11.01.03.0080.000184%
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.0010.000072%
Enuresis19.07.04.001; 20.02.02.0030.000184%Not Available
Epilepsy17.12.03.0020.001469%Not Available
Epistaxis22.04.03.001; 24.07.01.005--
Erection increased21.03.01.004; 19.08.04.0020.000184%Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythromelalgia24.03.01.001; 23.06.05.0020.000184%Not Available
Euphoric mood19.04.02.0060.001194%
Exostosis15.02.04.0050.000184%
Extrapyramidal disorder17.01.02.007--
Extrasystoles02.03.02.003--Not Available
Eye discharge06.04.05.001--Not Available
Eye disorder06.08.03.0010.000643%Not Available
Eye pain06.08.03.0020.000459%
Eye swelling06.08.03.003--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000275%Not Available
Facial paralysis17.04.03.0080.000459%Not Available
Faeces discoloured07.01.03.002--Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000048%Not Available
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