Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mesna
Drug ID BADD_D01398
Description Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]
Indications and Usage Mesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (2)
Marketing Status Prescription; Discontinued
ATC Code R05CB05; V03AF01
DrugBank ID DB09110
KEGG ID D01459
MeSH ID D015080
PubChem ID 23662354
TTD Drug ID D0C3YQ
NDC Product Code 0338-1307; 15308-0715; 0338-1305; 10019-951; 72643-007; 63323-733; 10019-953; 25021-201; 67108-3565; 58623-0039
Synonyms Mesna | Mesnum | Sodium 2-Mercaptoethanesulphonate | 2-Mercaptoethanesulphonate, Sodium | Ethanesulfonic acid, 2-mercapto-, monosodium salt | ASTA-D 7093 | ASTA D 7093 | ASTAD 7093 | Coenzyme M | MESNA-cell | MESNA cell | Mesnex | 2-Mercaptoethanesulfonate | 2 Mercaptoethanesulfonate | Mistabron | Mistabronco | Mucofluid | Mitexan | UCB-3983 | UCB 3983 | UCB3983 | Uromitexan | Ziken
Chemical Information
Molecular Formula C2H5NaO3S2
CAS Registry Number 19767-45-4
SMILES C(CS(=O)(=O)[O-])S.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Dehydration14.05.05.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Electrocardiogram ST segment elevation13.14.05.025--Not Available
Erythema23.03.06.001--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Granulocytopenia01.02.03.003--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
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