Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.008--Not Available
Fatigue08.01.01.0020.074478%
Feeling abnormal08.01.09.0140.017320%Not Available
Feeling cold08.01.09.0080.003175%Not Available
Feeling hot08.01.09.0090.002887%Not Available
Feeling jittery08.01.09.016--Not Available
Feeling of despair19.15.02.0060.000577%Not Available
Femoral neck fracture15.08.03.002; 12.04.01.002--Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Fibrin D dimer increased13.01.02.0360.000866%Not Available
Fibrosis08.03.01.0010.000577%Not Available
Fistula15.03.02.0010.000866%Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.002021%
Flatulence07.01.04.002--
Fluid overload14.05.06.001; 02.05.04.0040.020207%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.079963%Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.0020.008660%
Food poisoning12.03.01.024; 11.07.02.001; 07.11.01.0070.001155%Not Available
Foot fracture15.08.03.012; 12.04.01.0120.001732%Not Available
Fracture15.08.02.001; 12.04.02.001--
Fungal infection11.03.05.0010.006928%Not Available
Fungal skin infection11.03.05.002; 23.09.02.0010.000577%Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.014434%
Gallbladder disorder09.03.02.0010.002598%Not Available
Gamma-glutamyltransferase increased13.03.01.011--
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.0030.000866%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.003464%
Gastric ulcer07.04.03.002--
Gastritis07.08.02.0010.002309%
Gastrooesophageal reflux disease07.02.02.0030.007217%
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 29 Pages