Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anuria20.01.03.0020.001443%Not Available
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.000577%Not Available
Aortic stenosis24.04.01.0010.001155%Not Available
Aortic valve incompetence02.07.03.0010.000577%Not Available
Aortic valve stenosis02.07.03.0040.000577%Not Available
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.001--
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.0090.002598%
Aplastic anaemia01.03.03.0020.000226%Not Available
Appendicitis11.01.07.001; 07.19.01.0010.001443%
Arrhythmia02.03.02.0010.005773%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.006351%
Arthropathy15.01.01.0030.003175%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.007794%
Aspartate aminotransferase abnormal13.03.01.0040.000577%Not Available
Aspartate aminotransferase increased13.03.01.0060.007794%
Asphyxia12.01.08.011; 22.02.02.0010.000602%Not Available
Aspiration pleural cavity13.19.03.0020.002021%Not Available
Asthenia08.01.01.0010.038971%Not Available
Asthenopia06.01.01.0020.000577%Not Available
Asthma22.03.01.002; 10.01.03.0100.007217%Not Available
Atelectasis22.01.02.0010.001443%
Atrial fibrillation02.03.03.0020.022228%
Atrial flutter02.03.03.0030.002887%
Atrial septal defect03.07.02.002; 02.04.02.009--Not Available
Atrial tachycardia02.03.03.0040.000866%
Atypical pneumonia22.07.01.010; 11.01.09.0120.000577%Not Available
Autoimmune hepatitis10.04.09.001; 09.01.07.019--Not Available
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