Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Losartan
Drug ID BADD_D01322
Description Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.[L7423] Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough.[L7423] When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or [hydrochlorothiazide].[L7423] Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.[L7423,L7426] Patients taking losartan should have their renal function and potassium levels monitored.[L7423] Losartan was granted FDA approval on 14 April 1995.[L7423]
Indications and Usage Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hypertension.[L7423] Losartan with hydrochlorothiazide is indicated to treat hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage).[L7426]
Marketing Status approved
ATC Code C09CA01
DrugBank ID DB00678
KEGG ID D08146
MeSH ID D019808
PubChem ID 3961
TTD Drug ID D0DD0K
NDC Product Code 70010-741; 62207-742; 70010-742; 70010-743
UNII JMS50MPO89
Synonyms Losartan | 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol | DuP-753 | DuP 753 | DuP753 | MK-954 | MK 954 | MK954 | Cozaar | Losartan Potassium | Potassium, Losartan | Losartan Monopotassium Salt | Monopotassium Salt, Losartan | Salt, Losartan Monopotassium
Chemical Information
Molecular Formula C22H23ClN6O
CAS Registry Number 114798-26-4
SMILES CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Inflammation08.01.05.007; 10.02.01.0890.000061%Not Available
Limb discomfort15.03.04.0140.000027%Not Available
Abnormal behaviour19.01.01.0010.000030%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Feeling of body temperature change08.01.09.0120.000010%Not Available
Erectile dysfunction19.08.04.001; 21.03.01.007--
Psychiatric symptom19.01.02.0010.000015%Not Available
Ill-defined disorder08.01.03.049--Not Available
Sensation of foreign body08.01.09.0020.000020%Not Available
Urinary tract obstruction20.08.01.0040.000010%
Diabetic vascular disorder24.04.03.009; 14.07.05.001; 05.07.05.001--Not Available
Disease recurrence08.01.03.0500.000270%Not Available
Drug intolerance08.06.01.013--Not Available
Obstructive airways disorder22.03.01.0110.000045%Not Available
Renal mass20.01.02.0070.000010%Not Available
Renal impairment20.01.03.0100.000170%Not Available
Sinus disorder22.04.06.002--
Poor quality sleep17.15.04.002; 19.02.05.0050.000015%Not Available
Muscle contracture15.03.05.0240.000022%Not Available
Hypophagia07.01.06.010; 19.09.01.004; 14.03.01.0060.000020%Not Available
Lichenoid keratosis23.01.01.0040.000022%Not Available
Skin haemorrhage24.07.01.103; 23.06.07.0010.000022%Not Available
Chronic kidney disease20.01.03.0170.000030%
Mixed liver injury09.01.07.0150.000040%Not Available
Treatment failure08.06.01.0170.000086%Not Available
Liver injury12.01.17.012; 09.01.07.0220.000084%Not Available
Adverse reaction08.06.01.0180.000051%Not Available
Skin mass23.07.04.0140.000020%Not Available
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Acute kidney injury20.01.03.0160.000427%
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ADReCS-Target
Drug Name ADR Term Target
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