Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorcaserin hydrochloride hemihydrate
Drug ID BADD_D01320
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Indications and Usage For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Marketing Status Prescription
ATC Code A08AA11
DrugBank ID DB04871
KEGG ID D11566
MeSH ID C506658
PubChem ID 70678853
TTD Drug ID D01JMC
NDC Product Code 62856-535; 59651-017; 55111-973; 62856-529
Synonyms lorcaserin | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | Belviq | AR-10A | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | APD 356 | APD356 | APD-356
Chemical Information
Molecular Formula C22H32Cl4N2O
CAS Registry Number 856681-05-5
SMILES CC1CNCCC2=C1C=C(C=C2)Cl.CC1CNCCC2=C1C=C(C=C2)Cl.O.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.001--Not Available
Anxiety19.06.02.002--
Back pain15.03.04.005--
Blood prolactin increased13.10.03.002--Not Available
Cataract06.06.01.001--
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Euphoric mood19.04.02.006--
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Insomnia19.02.01.002; 17.15.03.002--
Lymphocyte count decreased13.01.06.006--
Muscle spasms15.05.03.004--
Musculoskeletal pain15.03.04.007--
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