Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Marketing Status OTC; Discontinued
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 51672-2085; 71335-1461; 52904-630; 72288-446; 21130-452; 55910-807; 63868-462; 0363-2131; 36800-363; 51660-754; 61474-4268; 50090-1454; 70000-0473; 61919-142; 67751-153; 55910-594; 24385-543; 11523-4329; 71335-0100; 37012-612; 67091-245; 11523-4359; 11523-7333; 0363-1612; 41250-612; 16714-898; 70518-2951; 54838-558; 54838-554; 63868-577; 53943-035; 49452-4135; 62207-787; 72288-901; 0363-0858; 24385-531; 56062-132; 81646-106; 11523-7157; 49348-818; 73581-203; 69168-414; 51927-4219; 68391-314; 11014-0031; 70000-0125; 50090-4316; 53943-975; 68071-4910; 30142-612; 41250-629; 55910-539; 50268-489; 11673-997; 21130-999; 71335-1651; 65015-803; 59556-301; 11523-4328; 63940-904; 56062-526; 66267-653; 68210-4110; 11523-1527; 79481-0446; 62938-0005; 71610-423; 55700-097; 80070-110; 0363-9995; 11822-3276; 0363-4020; 55154-4375; 68196-301; 68788-7653; 51660-753; 11822-0558; 55910-970; 0113-1191; 51079-246; 69842-337; 68016-131; 46122-539; 41163-364; 55910-612; 71309-007; 68016-167; 67751-163; 69842-085; 49035-953; 70677-0029; 41520-510; 59556-882; 63941-193; 25000-021; 50090-0836; 51672-2108; 59651-074; 51672-2092; 58602-830; 0904-6767; 55319-099; 73629-003; 70518-1335; 62993-0801; 37808-131; 72036-193; 63868-414; 11822-0446; 63941-131; 30142-723; 55910-611; 36800-755; 57344-193; 63187-100; 10888-8213; 11673-115; 53002-7490; 72983-501; 51001-2213; 63827-0001; 11822-2131; 11523-7202; 11523-6655; 70518-1399; 68071-4318; 70010-162; 0363-2108; 69842-686; 80159-103; 69230-322; 58602-821; 71610-553; 68071-4121; 30142-066; 0363-0699; 53117-407; 51660-527; 0615-8217; 59556-917; 0363-9603; 51660-112; 60000-950; 41163-633; 66577-046; 0113-0671; 53943-193; 11523-4331; 70677-0134; 66577-012; 50090-4300; 11523-7160; 50090-5532; 0113-1612; 62011-0371; 21130-139; 11523-7200; 0904-6852; 69842-894; 21130-301; 69842-540; 68788-7291; 68016-094; 50090-4266; 68554-0003; 41250-890; 65015-684; 53117-309; 41520-612; 41226-686; 49035-806; 68788-7769; 71141-132; 70677-0145; 63941-526; 70518-0135; 69842-954; 56062-990; 51660-106; 69842-895; 0363-1686; 0363-0754; 11673-996; 62011-0248; 55681-303; 11523-4360; 41250-716; 47682-913; 80070-120; 56062-900; 49035-061; 72288-612; 68071-2392; 63654-309; 51672-2131; 55910-629; 0904-6632; 38779-2857; 50090-2387; 0363-0752; 45802-650; 68391-301; 57243-200; 0113-7612; 65691-0042; 11523-0007; 30142-984; 21130-646; 36800-853; 68071-3208; 51316-502; 0113-9755; 37808-529; 55301-612; 17856-0557; 70000-0583; 69842-953; 59726-915; 54473-166; 11673-111; 37205-378; 62938-0004; 68210-4126; 55289-728; 0113-7671; 41163-612; 36800-608; 58602-744; 63552-038; 72983-500; 63629-7772; 68998-309; 70000-0252; 43353-259; 51672-2073; 59726-758; 63868-669; 49035-538; 59651-035; 55154-4976; 69168-407; 0113-7500; 37808-506; 16571-822; 59779-528; 63629-1329; 69848-019; 11822-7240; 69842-535; 11822-8329; 68001-438; 0113-1719; 0363-9150; 69842-242; 50090-5506; 41520-716; 11523-7237; 70000-0213; 50090-5067; 41250-539; 67091-350; 68998-407; 69452-283; 69168-309; 68071-5049; 72888-029; 68071-2208; 0113-0612; 67091-246; 11523-0800; 30142-996; 63548-0753; 62331-018; 0536-1092; 55315-528; 53943-116; 50090-3464; 51316-503; 50090-3943; 68016-053; 65015-802; 68016-088; 51824-075; 58602-831; 63981-612; 62011-0348; 69452-211; 46122-423; 21130-123; 68016-055; 72288-200; 50804-840; 81522-612; 69256-612; 51660-526; 11822-2022; 55154-8082; 11673-986; 11523-4330; 11822-0919
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.000291%Not Available
Nightmare19.02.03.003--Not Available
Ocular hyperaemia06.04.05.0040.000146%Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.000146%
Pain08.01.08.0040.000728%
Pain in extremity15.03.04.0100.000219%
Palpitations02.01.02.0030.000291%
Pancreatitis07.18.01.0010.000146%
Paraesthesia17.02.06.005--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pollakiuria20.02.02.007--
Pruritus23.03.12.0010.000364%
Pulmonary embolism24.01.06.001; 22.06.02.0010.000291%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.0010.000437%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.0010.000146%
Rheumatoid arthritis10.04.06.001; 15.01.03.0010.000146%Not Available
Rhinorrhoea22.02.05.0100.000219%
Rotator cuff syndrome15.01.08.002; 12.04.03.0020.000146%
Salivary hypersecretion07.06.01.009--Not Available
Scar23.03.11.008; 12.01.06.0080.000146%Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.0050.000146%
Skin disorder23.03.03.007--Not Available
Sneezing22.02.05.0110.000219%
Somnolence19.02.05.003; 17.02.04.0060.000656%
Suicide attempt19.12.01.0040.000146%
Syncope17.02.04.008; 02.01.02.008; 24.06.02.0120.000146%
Tachycardia02.03.02.0070.000219%Not Available
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