Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide hydrochloride
Drug ID BADD_D01315
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status Prescription; OTC; Discontinued
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D00729
MeSH ID D008139
PubChem ID 71420
TTD Drug ID D0CS2F
NDC Product Code 12578-409; 69842-061; 62011-0236; 71335-1569; 41520-841; 58602-701; 53329-664; 67296-0346; 55315-123; 24385-554; 50090-0460; 50580-134; 55289-315; 70518-0072; 49035-520; 55154-5585; 49452-4133; 41250-224; 71335-1921; 60687-229; 46122-581; 68016-123; 48292-0029; 63941-123; 71205-079; 17337-0053; 36800-224; 0904-7725; 52904-443; 35418-123; 68016-058; 66577-015; 49035-224; 68094-129; 63981-224; 63187-462; 50580-367; 68094-029; 59651-022; 33992-0820; 70000-0461; 59556-959; 67751-162; 70518-0313; 59779-700; 11673-177; 51927-2357; 63868-748; 50580-317; 50383-618; 36800-208; 41520-520; 0093-0311; 30142-998; 68071-2257; 51660-123; 70677-0060; 41250-210; 51927-0174; 56062-224; 30142-520; 42799-605; 55910-224; 49632-070; 41250-520; 42708-074; 59779-520; 69452-176; 10888-8117; 72288-758; 55910-176; 63868-338; 73581-101; 37808-988; 11673-224; 42961-048; 68998-123; 50804-520; 66715-9859; 53943-176; 62011-0390; 66715-5759; 68391-224; 49035-483; 55154-4699; 71335-2061; 17337-0526; 10888-8123; 49348-529; 63629-8747; 69452-271; 55910-520; 0615-8087; 71205-316; 0113-0224; 11822-7834; 55910-700; 68788-9773; 61919-423; 68788-8951; 63629-1452; 63629-8193; 53943-123; 69452-266; 47682-200; 73581-102; 67544-700; 66267-132; 70518-3400; 38779-0446; 43063-020; 68981-022; 30142-159; 80136-851; 58602-870; 51079-690; 63868-876; 10888-8122; 0363-1176; 0378-2100; 70518-0893; 17337-0052
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H34Cl2N2O2
CAS Registry Number 34552-83-5
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Constipation07.02.02.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Ileus paralytic07.02.05.001--Not Available
Megacolon07.02.05.002--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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