Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Liothyronine
Drug ID BADD_D01296
Description Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.[T457] The exogenous liothyronine product was developed by King Pharmaceuticals and FDA approved in 1956.[L5578]
Indications and Usage Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis.
Marketing Status Prescription
ATC Code H03AA02
DrugBank ID DB00279
KEGG ID D01011
MeSH ID D014284
PubChem ID 5920
TTD Drug ID D0S6JG
NDC Product Code Not Available
Synonyms Triiodothyronine | T3 Thyroid Hormone | Thyroid Hormone, T3 | Liothyronine | 3,3',5-Triiodothyronine | Liothyronine Sodium | Cytomel
Chemical Information
Molecular Formula C15H12I3NO4
CAS Registry Number 15785-49-6
SMILES C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.0010.003682%
Insomnia19.02.01.002; 17.15.03.0020.002455%
Malaise08.01.01.0030.004909%
Migraine24.03.05.003; 17.14.02.0010.001227%Not Available
Muscle twitching15.05.03.005--Not Available
Musculoskeletal pain15.03.04.0070.001841%
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocarditis02.04.03.0010.001227%
Nausea07.01.07.001--
Pain in extremity15.03.04.0100.001227%
Palpitations02.01.02.0030.005523%
Phlebitis24.05.03.001; 12.02.01.002--
Pruritus23.03.12.0010.001227%
Pulmonary embolism24.01.06.001; 22.06.02.0010.001227%Not Available
Rash generalised23.03.13.0020.001227%Not Available
Sluggishness08.01.01.0040.001227%Not Available
Swelling face23.04.01.018; 10.01.05.0180.001227%Not Available
Tachycardia02.03.02.007--Not Available
Thyroid function test abnormal13.10.06.0010.001227%Not Available
Visual impairment06.02.06.0080.001227%Not Available
Weight increased13.15.01.0060.003682%
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Congestive cardiomyopathy02.04.01.0030.001841%Not Available
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.001841%Not Available
Thyrotoxic periodic paralysis17.01.04.021; 14.11.01.045; 05.02.02.0050.002455%Not Available
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