Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levomilnacipran hydrochloride
Drug ID BADD_D01280
Description Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, levomilnacipran is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.
Indications and Usage Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD).
Marketing Status Prescription; Discontinued
ATC Code N06AX28
DrugBank ID DB08918
KEGG ID D10133
MeSH ID D000078862
PubChem ID 6917778
TTD Drug ID D02XOK
NDC Product Code 50370-0043; 0456-2213; 0456-2280; 0456-2212; 0456-2281; 69766-018; 0456-2241; 0456-2221; 0456-2202; 51604-1183; 53069-1090; 53069-1100; 0456-2240; 0456-2220
Synonyms Levomilnacipran | Fetzima | Levomilnacipran Hydrochloride
Chemical Information
Molecular Formula C15H23ClN2O
CAS Registry Number 101152-94-7
SMILES CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Heart rate increased13.14.04.002--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypomania19.16.02.001--Not Available
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Mania19.16.02.002--
Menopausal symptoms21.02.02.002--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Palpitations02.01.02.003--
Panic attack19.06.04.001--Not Available
Paraesthesia17.02.06.005--
Pollakiuria20.02.02.007--
Premature ejaculation19.08.01.002; 21.03.01.008--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Rash generalised23.03.13.002--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.004--
Seizure17.12.03.001--
Seminal vesiculitis21.09.01.004--Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.041--Not Available
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