Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76282-247; 65162-538; 28877-5960; 50474-001; 68180-113; 63739-411; 69367-333; 51991-651; 68001-114; 70518-1921; 51927-0107; 42385-957; 0409-1886; 60505-3517; 16714-034; 70518-1796; 63629-8315; 55111-870; 60687-249; 24689-106; 51552-1448; 50474-597; 47335-576; 16714-358; 55154-7887; 50474-596; 55154-5782; 43485-104; 72865-188; 69102-106; 0121-0799; 63629-4675; 51672-4136; 63323-400; 65841-703; 0378-5617; 0904-6051; 68001-117; 66689-028; 68084-859; 13668-017; 43547-346; 14789-110; 0378-5613; 55111-182; 25021-780; 12666-0014; 68382-168; 52343-071; 16714-355; 35208-031; 13668-016; 16571-788; 43547-221; 31722-574; 68180-112; 65862-245; 54838-548; 63629-4137; 42185-7039; 10370-195; 10370-214; 0121-2397; 61919-559; 0409-2011; 16571-787; 68180-114; 43547-223; 66689-029; 43063-499; 76494-530; 66174-0044; 47133-574; 52343-072; 72789-152; 75834-246; 52038-171; 60505-3518; 80705-101; 76282-246; 76494-529; 71930-063; 51927-0088; 68083-153; 71052-043; 69076-500; 38779-2900; 68001-402; 44567-501; 50090-4023; 70860-602; 16714-357; 64980-365; 65862-247; 62331-010; 0904-7060; 68084-882; 51672-4141; 50474-599; 68083-152; 47335-573; 68554-0065; 68001-115; 67457-790; 68084-870; 55154-5699; 0615-7978; 0121-4799; 71093-144; 43485-102; 64980-363; 65162-529; 0378-5615; 65162-528; 16729-065; 70518-2320; 63187-360; 43485-103; 69102-107; 0904-7124; 50228-190; 0904-6052; 72189-190; 50090-3518; 71930-065; 68001-405; 0143-9574; 16571-789; 67296-1248; 70518-0947; 55111-183; 63739-787; 36998-0117; 68180-117; 65862-261; 55154-3367; 71335-0139; 64980-362; 16714-310; 17856-0574; 68084-893; 72865-189; 0904-7123; 60432-831; 43547-222; 60429-349; 50228-189; 68071-4508; 68180-118; 0395-8160; 50268-470; 71930-062; 50090-2456; 36998-5980; 69339-157; 64220-192; 68788-7074; 13668-014; 72485-106; 69367-332; 35208-032; 55111-248; 61919-068; 65372-1148; 16714-035; 36998-5950; 28877-5970; 69076-750; 70518-1969; 51672-4142; 68083-154; 52343-069; 52343-070; 50474-598; 65862-315; 51672-4137; 61919-552; 36998-5960; 51927-0155; 72643-025; 71901-605; 16571-790; 81414-001; 44567-502; 71205-880; 65841-704; 68382-165; 66689-030; 0904-7125; 68001-404; 70166-081; 51927-4721; 63629-7516; 58032-0132; 55154-7647; 13668-015; 43063-617; 50383-241; 69102-108; 67296-1636; 51079-821; 50090-2875; 16714-356; 36998-5970; 65862-246; 0472-0235; 43489-122; 69102-105; 81646-116; 62756-880; 50090-3264; 50228-472; 71335-0748; 71335-0048; 0121-1598; 75834-245; 68001-118; 14789-330; 71930-064; 61919-685; 14789-220; 50090-3889; 81665-100; 50474-594; 68001-113; 16714-354; 16729-067; 57572-0034; 63739-019; 55150-177; 42385-955; 65162-685; 58118-1112; 68788-7430; 42385-956; 76282-248; 70518-2810; 50228-473; 50090-1333; 67835-0006; 71335-0702; 70518-3317; 31722-539; 68180-115; 67457-266; 31722-538; 71335-0694; 64220-152; 66689-102; 43547-224; 47133-575; 36998-5990; 64376-697; 50474-002; 16729-064; 39822-4000; 76494-531; 70860-604; 62512-0030; 43547-345; 42385-954; 72640-004; 0615-7979; 80705-100; 51672-4143; 70860-603; 76494-528; 50090-5495; 44567-500; 50090-5760; 67457-265; 65162-539; 64980-364; 68001-116; 43489-124; 72969-039; 16729-066; 68788-7884; 72865-187; 68180-099; 72189-229; 70518-2230; 0615-7976; 0378-5619; 36998-5940; 31722-536; 43485-101; 68788-7534; 55111-181; 72865-190; 51224-013; 42571-331; 70518-1998; 60429-350; 0904-6053; 67457-255; 63629-2073; 70518-2328; 65862-250; 50474-595; 50683-0322; 60505-3280; 70518-1901; 62350-0059; 0143-9673; 31722-537; 68001-403; 71205-881; 70518-3192; 44567-503; 55289-097; 28877-5950; 63739-795; 68225-021; 0615-7977; 16714-537
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis bullous23.03.01.0020.001714%
Developmental delay08.01.03.0370.004761%Not Available
Diabetes insipidus14.05.07.003; 05.03.03.0040.000298%Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diet refusal14.03.01.0110.000571%Not Available
Dilatation ventricular02.04.02.0260.000381%Not Available
Diplopia06.02.06.002; 17.17.01.005--Not Available
Discomfort08.01.08.003--Not Available
Disinhibition19.05.01.0020.000381%Not Available
Disorientation19.13.01.002; 17.02.05.0150.004380%Not Available
Dissociation19.14.01.0020.000571%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.008379%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drooling17.02.05.0050.000762%Not Available
Drug abuse19.07.02.010--Not Available
Drug dependence19.07.02.009--Not Available
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.0150.002095%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug interaction08.06.03.001--Not Available
Drug level increased13.17.01.004--Not Available
Drug withdrawal convulsions17.12.03.016; 08.06.02.0030.001143%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Drug withdrawal syndrome neonatal19.07.02.012; 18.04.13.001; 08.06.02.0080.001523%Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysaesthesia17.02.06.0030.000571%
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.003428%
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