Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lanreotide acetate
Drug ID BADD_D01244
Description Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured by the company, _Ipsen Pharmaceuticals_ as lanreotide acetate, and marketed as _Somatuline_. It is approved in several countries worldwide, including the United Kingdom, Australia, and Canada. Lanreotide was first approved for use in the United States by the FDA on August 30, 2007.
Indications and Usage Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2)
Marketing Status Prescription
ATC Code H01CB03
DrugBank ID DB06791
KEGG ID D04666
MeSH ID C060347
PubChem ID 71349
TTD Drug ID D0M2YE
NDC Product Code 32861-0006; 71161-114; 15054-1120; 69097-890; 71161-116; 52076-6264; 35207-0011; 71161-115; 15054-1090; 69097-870; 69097-880; 52076-6272; 15054-1060
Synonyms lanreotide | 3-(2-naphthyl)alanyl-cystinyl-tyrosyl-tryptophyl-lysyl-valyl-cystinyl-threonine amide | D-Nal-Cys-Tyr-Trp-Lys-Val-Cys-Thr-NH2 | angiopeptin | naphthalenyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)threoninamide | L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)-Thr-NH2 | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide | 3-(2-naphthyl)-D-Ala-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 | naphthyl-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | BIM 23014 | BIM-23014 | DC 13-116 | DC13-116 | DC-13-116 | lanreotide acetate | Somatulina | Somatuline | lanreotide-SR | BIM 23014 C | BIM 23014C | BIM-23014 C | 188Re-lanreotide | Somatulin
Chemical Information
Molecular Formula C54H69N11O10S2
CAS Registry Number 108736-35-2
SMILES CC(C)C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC 4=CC=C(C=C4)O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)N)C(=O)NC(C(C)O)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Aortic valve incompetence02.07.03.001--Not Available
Aortic valve stenosis02.07.03.004--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrial septal defect03.07.02.002; 02.04.02.009--Not Available
Atrioventricular block02.03.01.002--Not Available
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Back pain15.03.04.005--
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bundle branch block02.03.01.009--Not Available
Bursitis15.04.01.001--Not Available
Cardiac murmur13.14.01.001--Not Available
Cardiomegaly02.04.02.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.001--
Change of bowel habit07.02.03.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.002--Not Available
Constipation07.02.02.001--
Corneal deposits06.06.03.002--Not Available
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