Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lacosamide
Drug ID BADD_D01238
Description Lacosamide is a functionalized amino acid that has activity in the maximal electroshock seizure test, and is indicated for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Recent studies indicate that Lacosamide only affects those neurons which are depolarized or active for long periods of time, typical of neurons at the focus of an epileptic seizure, as opposed to other antiepileptic drugs such as carbamazepine or lamotrigine which slow the recovery from inactivation and reduce the ability of neurons to fire action potentials.
Indications and Usage Lacosamide is indicated for adjunctive therapy for partial onset seizures in patients with epilepsy over 17 years old. Injection is indicated for short term use when oral therapy is not feasible.
Marketing Status Prescription
ATC Code N03AX18
DrugBank ID DB06218
KEGG ID D07299
MeSH ID D000078334
PubChem ID 219078
TTD Drug ID D05OFX
NDC Product Code 66689-108; 52038-005; 36998-1810; 27808-245; 50228-195; 69539-026; 36998-2477; 67877-733; 68462-678; 14445-012; 65977-0075; 14445-130; 50370-0024; 36998-2478; 68462-681; 65162-925; 47335-922; 69539-025; 0131-5410; 51991-349; 51991-350; 65162-924; 0131-1810; 62331-062; 69539-027; 51991-351; 36998-0119; 36998-2480; 65862-720; 66689-107; 50228-194; 27808-246; 31722-815; 0131-2479; 62332-172; 51991-348; 46708-860; 50228-192; 31722-814; 53296-0101; 0904-7247; 14445-129; 0904-7245; 68462-679; 66689-109; 50228-193; 36998-2479; 17205-107; 25021-791; 13612-0021; 65162-926; 62332-173; 0131-2477; 31722-812; 62332-171; 66651-914; 70166-617; 16436-0101; 67877-735; 14445-406; 14445-132; 66039-882; 67877-736; 0904-7246; 14445-021; 69539-028; 17180-2746; 27808-243; 62332-174; 67877-734; 31722-813; 47335-980; 65372-1186; 0131-2480; 47335-943; 66689-110; 0904-7244; 68225-057; 14445-131; 68462-680; 53747-069; 47335-918; 0131-2478; 27808-244; 12828-0087; 65162-923
Synonyms Lacosamide | Vimpat | N-benzyl-2-acetamido-3-methoxypropionamide | N benzyl 2 acetamido 3 methoxypropionamide | N-benzyl-AcMeOPrNH2 | N benzyl AcMeOPrNH2
Chemical Information
Molecular Formula C13H18N2O3
CAS Registry Number 175481-36-4
SMILES CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash macular23.03.13.0030.006704%Not Available
Rash maculo-papular23.03.13.0040.020111%
Rash morbilliform23.03.13.0050.010056%Not Available
Rash pruritic23.03.12.002--Not Available
Renal failure20.01.03.005--Not Available
Respiratory acidosis14.01.04.002; 22.02.02.0040.006704%Not Available
Respiratory disorder22.02.07.0020.010056%Not Available
Restlessness19.11.02.002; 17.02.05.0210.020111%
Retinal vascular occlusion24.04.10.004; 06.10.01.0080.006704%Not Available
Rhabdomyolysis15.05.05.0020.023463%
Salivary hypersecretion07.06.01.0090.013408%Not Available
Seizure17.12.03.0010.780990%
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Sexual dysfunction21.03.02.003; 19.08.05.0020.006704%Not Available
Shock24.06.02.002--Not Available
Sinus arrest02.03.03.0070.006704%Not Available
Sinus arrhythmia02.03.03.0080.006704%Not Available
Sinus bradycardia02.03.03.0090.020111%
Sinus tachycardia02.03.03.0100.006704%
Skin disorder23.03.03.007--Not Available
Skin reaction23.03.03.013; 10.01.03.0190.010056%Not Available
Sleep disorder19.02.04.0010.013408%Not Available
Somnolence17.02.04.006; 19.02.05.0030.080445%
Speech disorder17.02.08.003; 22.02.05.034; 19.19.02.0020.010056%Not Available
Status epilepticus17.12.03.0050.137427%Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Sudden death08.04.01.003; 02.03.04.0130.002623%
Suicidal ideation19.12.01.0030.060334%
Suicide attempt19.12.01.0040.053630%
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 12 Pages