Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir sulfate
Drug ID BADD_D01151
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID D00897
MeSH ID D019469
PubChem ID 5462355
TTD Drug ID D0V7CF
NDC Product Code 0006-0573; 0006-0571
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H49N5O8S
CAS Registry Number 157810-81-6
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceLipoprotein lipaseP06858T28692Not Available
Insulin resistanceAdiponectinQ15848T15572Not Available
Insulin resistanceAP-2 complex subunit betaP63010Not AvailableNot Available
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Ingrowing nail23.02.05.011--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Malaise08.01.01.003--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Neutrophil count decreased13.01.06.010--
Pancreatitis07.18.01.001--
Paronychia23.09.04.001; 11.01.12.001--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count decreased13.01.04.001--
Pruritus23.03.12.001--
Pyelonephritis20.01.09.001; 11.01.14.002--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Skin hyperpigmentation23.05.01.003--
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
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