ADReCS

Pharmaceutical Information

Drug Name	Iloprost
Drug ID	BADD_D01135
Description	Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage	Used for the treatment of pulmonary arterial hypertension.
Marketing Status	approved; investigational
ATC Code	B01AC11
DrugBank ID	DB01088
KEGG ID	D02721
MeSH ID	D016285
PubChem ID	5311181
TTD Drug ID	D05ZTH
NDC Product Code	66215-303; 40016-013; 82231-109; 54893-0017; 66215-302
UNII	JED5K35YGL
Synonyms	Iloprost \| Ciloprost \| ZK-36374 \| ZK 36374 \| ZK36374 \| Ventavis

Chemical Information

Molecular Formula	C22H32O4
CAS Registry Number	78919-13-8
SMILES	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Premature baby	18.04.02.001	0.000329%		Not Available
Productive cough	22.02.03.005	0.000716%
Pulmonary congestion	24.03.08.001; 22.01.03.002; 02.05.02.002	0.000123%		Not Available
Pulmonary fibrosis	22.01.02.006	0.000329%
Pulmonary haemorrhage	24.07.01.016; 22.12.01.009	0.000123%
Pulmonary hypertension	24.08.03.002; 22.06.01.001	0.003495%
Pulmonary oedema	22.01.03.003; 02.05.02.003	0.001110%
Pulmonary thrombosis	24.01.06.002; 22.06.02.003	0.000082%		Not Available
Pulmonary veno-occlusive disease	22.06.03.003; 24.01.06.008	0.000082%		Not Available
Rales	22.12.01.011	0.000082%		Not Available
Rash	23.03.13.001	-	-	Not Available
Renal disorder	20.01.02.002	0.000493%		Not Available
Renal failure	20.01.03.005	0.000740%		Not Available
Respiratory arrest	22.02.01.009	0.000370%		Not Available
Respiratory disorder	22.02.07.002	0.000452%		Not Available
Respiratory distress	22.02.01.012	0.000535%		Not Available
Respiratory failure	22.02.06.002; 14.01.04.003	0.001398%
Right ventricular failure	02.05.03.002	0.000781%		Not Available
Sarcoidosis	10.02.06.001	0.000123%		Not Available
Scleroderma	23.03.02.005; 15.06.01.002; 10.04.07.001	0.000288%		Not Available
Shock	24.06.02.002	0.000123%		Not Available
Sickle cell anaemia with crisis	01.04.02.001	0.000082%		Not Available
Sinus headache	22.12.03.022; 17.14.01.002	0.000082%
Skin cancer	23.08.02.002; 16.03.02.002	0.000123%		Not Available
Skin disorder	23.03.03.007	-	-	Not Available
Skin odour abnormal	23.03.03.012	0.000181%
Skin ulcer	23.07.03.003; 24.04.03.007	0.000206%
Sleep apnoea syndrome	22.02.01.013; 19.02.05.002; 17.15.05.001	0.000082%
Speech disorder	22.12.03.027; 19.19.02.002; 17.02.08.003	0.000345%		Not Available
Sputum increased	22.02.03.007	0.000123%		Not Available

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