Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematoma24.07.01.001--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis22.02.03.004; 02.01.02.006; 24.07.01.0060.000629%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.000371%Not Available
Hand fracture12.04.01.014; 15.08.03.0140.000371%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.000371%Not Available
Heart rate increased13.14.04.002--Not Available
Hepatic cirrhosis09.01.04.0010.000194%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000371%Not Available
Hepatic failure09.01.03.002--
Hepatic neoplasm09.04.03.001; 16.07.03.0010.000742%Not Available
Hip fracture15.08.03.001; 12.04.01.0010.000742%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.000556%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.0020.004081%
Hypoxia22.02.02.0030.000532%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza11.05.03.001; 22.07.02.0010.003153%Not Available
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
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