Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ifosfamide
Drug ID BADD_D01133
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Indications and Usage Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01AA06
DrugBank ID DB01181
KEGG ID D00343
MeSH ID D007069
PubChem ID 3690
TTD Drug ID D02TLO
NDC Product Code 10019-925; 63323-142; 15308-0411; 10019-929; 57884-0006; 0338-3991; 0143-9530; 10019-926; 0143-9531; 10019-927; 65124-0001; 0703-3427; 0338-3993; 0703-3429
Synonyms Ifosfamide | Isofosfamide | Isophosphamide | Iphosphamide | Iso-Endoxan | Iso Endoxan | Holoxan | NSC-109,724 | NSC 109,724 | NSC109,724 | NSC-109724 | NSC 109724 | NSC109724 | Asta Z 4942
Chemical Information
Molecular Formula C7H15Cl2N2O2P
CAS Registry Number 3778-73-2
SMILES C1CN(P(=O)(OC1)NCCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AminoaciduriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
AnxietyAlpha-2A adrenergic receptorP08913T114487938249; 11425914
Arterial disorderElastinP15502Not Available2184650; 4077233; 10491730; 7033951; 3341387; 6489195; 2184657; 6394516; 6869203; 6616523; 9486085; 3277415; 11026649; 8562468; 6856486
Drug toleranceAlpha-2A adrenergic receptorP08913T114487938249; 11425914
GlycosuriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
HypophosphataemiaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
Metabolic disorderS-adenosylmethionine decarboxylase proenzymeP17707T559226305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
Metabolic disorderOrnithine decarboxylaseP11926T603666305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neuropathy peripheral17.09.03.0030.000799%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.005328%Not Available
Neutropenia01.02.03.0040.005062%Not Available
Neutrophil count decreased13.01.06.0100.001066%
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oligohydramnios18.05.01.0010.000533%Not Available
Oligospermia21.03.03.005--
Osteoarthritis15.01.04.001--Not Available
Osteomalacia20.01.01.002; 15.02.03.001; 14.04.04.001--Not Available
Ovarian disorder21.11.02.0040.000799%Not Available
Ovarian failure21.11.02.005; 05.05.01.012--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.000799%
Palmar-plantar erythrodysaesthesia syndrome17.02.07.009; 23.07.04.001--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.0030.000799%Not Available
Panic attack19.06.04.001--Not Available
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Pericardial effusion02.06.01.002--
Pericarditis02.06.02.001--
Perseveration19.10.03.005--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Platelet count decreased13.01.04.0010.001332%
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonitis22.01.01.006--
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