Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ifosfamide
Drug ID BADD_D01133
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Indications and Usage Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01AA06
DrugBank ID DB01181
KEGG ID D00343
MeSH ID D007069
PubChem ID 3690
TTD Drug ID D02TLO
NDC Product Code 10019-925; 63323-142; 15308-0411; 10019-929; 57884-0006; 0338-3991; 0143-9530; 10019-926; 0143-9531; 10019-927; 65124-0001; 0703-3427; 0338-3993; 0703-3429
Synonyms Ifosfamide | Isofosfamide | Isophosphamide | Iphosphamide | Iso-Endoxan | Iso Endoxan | Holoxan | NSC-109,724 | NSC 109,724 | NSC109,724 | NSC-109724 | NSC 109724 | NSC109724 | Asta Z 4942
Chemical Information
Molecular Formula C7H15Cl2N2O2P
CAS Registry Number 3778-73-2
SMILES C1CN(P(=O)(OC1)NCCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AminoaciduriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
AnxietyAlpha-2A adrenergic receptorP08913T114487938249; 11425914
Arterial disorderElastinP15502Not Available2184650; 4077233; 10491730; 7033951; 3341387; 6489195; 2184657; 6394516; 6869203; 6616523; 9486085; 3277415; 11026649; 8562468; 6856486
Drug toleranceAlpha-2A adrenergic receptorP08913T114487938249; 11425914
GlycosuriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
HypophosphataemiaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
Metabolic disorderS-adenosylmethionine decarboxylase proenzymeP17707T559226305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
Metabolic disorderOrnithine decarboxylaseP11926T603666305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endocrine disorder05.09.01.001--Not Available
Enterocolitis07.08.03.003--
Enuresis20.02.02.003; 19.07.04.001--Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extrapyramidal disorder17.01.02.007--
Extravasation08.01.03.008--Not Available
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.001--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.004263%
Feeling abnormal08.01.09.014--Not Available
Fluid overload14.05.06.001; 02.05.04.0040.000799%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Fungal infection11.03.05.001--Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.000533%
Gastrointestinal disorder07.11.01.0010.001066%Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal pain07.01.05.005--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.001--
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.000139%Not Available
Hallucination19.10.02.002--
Hallucination, auditory19.10.02.003--Not Available
Hallucination, visual19.10.02.0040.000533%Not Available
Hepatic failure09.01.03.002--
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