Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cellulitis23.09.01.001; 11.02.01.0010.001066%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000625%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.002931%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.000799%
Cholecystitis09.03.01.0010.000139%
Cholelithiasis09.03.01.0020.000799%Not Available
Cholestasis09.01.01.0010.000533%Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.000486%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000139%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000556%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.0010.003730%
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.0030.000533%Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Dementia19.20.02.001; 17.03.01.0010.001598%Not Available
Depressed level of consciousness17.02.04.0020.001332%
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000799%
Dermatomyositis23.03.02.001; 10.04.02.001; 15.05.01.0020.001865%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.000533%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000347%
Diverticulitis07.10.02.001; 11.01.07.0030.000533%Not Available
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