Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthma22.03.01.002; 10.01.03.0100.000799%Not Available
Atrial fibrillation02.03.03.0020.001332%
Atrophy08.03.04.001--Not Available
Azoospermia21.03.03.0010.000533%
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.0010.002931%Not Available
Bile duct stone09.02.02.0030.000533%Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.01.0080.000533%
Blood creatine phosphokinase increased13.04.01.0010.000533%
Blood creatinine increased13.13.01.0040.001332%
Blood iron decreased13.11.01.006--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.002131%
Blood pressure decreased13.14.03.002--Not Available
Blood pressure systolic increased13.14.03.0060.000533%Not Available
Blood sodium decreased13.11.01.0120.000533%Not Available
Blood urea increased13.13.01.0060.001066%Not Available
Blood uric acid increased13.02.04.0010.000799%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.000533%Not Available
Bone pain15.02.01.0010.000533%
Bowen's disease23.08.02.004; 16.03.02.0040.002398%Not Available
Breast cancer16.10.01.001; 21.05.01.0030.002398%Not Available
Bromosulphthalein test abnormal13.03.01.022--Not Available
C-reactive protein increased13.09.01.0070.000799%Not Available
Cardiac arrest02.03.04.0010.000417%
Cardiac failure02.05.01.0010.000903%
Cardiomegaly02.04.02.0010.000208%Not Available
Cataract06.06.01.0010.000533%
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