Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrochlorothiazide
Drug ID BADD_D01083
Description Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Indications and Usage Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450]
Marketing Status approved; vet_approved
ATC Code C03AA03
DrugBank ID DB00999
KEGG ID D00340
MeSH ID D006852
PubChem ID 3639
TTD Drug ID D0U4UQ
NDC Product Code 65862-113; 42708-079; 0172-2089; 50090-1088; 50090-6158; 51655-272; 53002-4970; 57237-002; 62135-448; 63629-1219; 65862-133; 68071-3443; 68071-4963; 68071-5211; 69315-155; 70518-0335; 70518-2540; 70934-916; 71335-1451; 72789-176; 72789-296; 0591-0347; 55488-0300; 42708-028; 50090-6157; 51407-332; 58118-0123; 60687-593; 60687-683; 60760-499; 62135-449; 63187-441; 63629-7782; 63629-8992; 68071-3238; 68071-5284; 68788-8378; 68788-8928; 70934-789; 70934-930; 71205-090; 71205-161; 71610-015; 71610-276; 71610-697; 76282-155; 65862-323; 42708-086; 42708-164; 50090-0724; 53002-4972; 61919-293; 62332-070; 0527-1413; 70518-2629; 71205-793; 71335-0145; 71335-0652; 71335-1481; 71335-9647; 61919-580; 61919-695; 63629-1220; 67296-1487; 67296-1508; 68645-510; 68788-8417; 69584-362; 70518-1676; 71610-261; 72189-263; 57451-1127; 16729-182; 29300-128; 29300-129; 43353-240; 43353-719; 43547-398; 50090-5672; 50090-6156; 51655-088; 51655-502; 51655-616; 0228-2820; 63629-1218; 63629-8991; 68788-6844; 68788-8126; 69584-361; 70518-1728; 70518-2550; 70518-2666; 70934-170; 71335-0770; 0615-8449; 72789-303; 11722-060; 42419-001; 65862-134; 43063-747; 50268-404; 51655-522; 55700-006; 60760-430; 63187-440; 68071-2654; 68071-5266; 69315-130; 70518-3633; 70518-3749; 71205-589; 71205-980; 71335-0269; 12658-0405; 49452-3575; 23155-009; 35356-807; 43063-755; 50090-2744; 50090-6372; 63187-074; 63629-1121; 67296-2043; 67544-739; 68071-5273; 68788-7683; 70518-1595; 71335-1350; 71610-139; 71610-500; 0615-8450; 51927-0172; 51927-1611; 57451-1143; 16729-184; 23155-008; 23155-764; 43547-397; 50090-2727; 50090-5333; 50090-6532; 50228-111; 59746-382; 60760-199; 67296-1274; 68071-2159; 68788-7790; 69315-131; 69367-219; 0527-1414; 70518-0597; 70934-883; 71205-419; 71205-751; 71335-1713; 71610-014; 71610-471; 0615-8149; 12658-0605; 29300-130; 42708-027; 43353-717; 0172-2083; 50090-2706; 51655-674; 53002-1702; 53808-1111; 60760-315; 63187-367; 63187-548; 63629-8498; 68071-2607; 70934-074; 0615-7974; 12828-0008; 62512-0028; 43063-933; 50228-146; 51407-330; 51655-422; 51655-515; 51655-831; 63187-553; 67296-1174; 70518-0210; 70518-1486; 71335-0067; 71335-1976; 71610-488; 76282-154; 12658-0538; 16729-183; 46708-438; 50090-2171; 50228-112; 51407-331
UNII 0J48LPH2TH
Synonyms Hydrochlorothiazide | HCTZ | Dichlothiazide | Dihydrochlorothiazide | HydroDIURIL | Oretic | Sectrazide | Esidrix | Esidrex | Hypothiazide
Chemical Information
Molecular Formula C7H8ClN3O4S2
CAS Registry Number 58-93-5
SMILES C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Stomatitis07.05.06.005--
Stress19.06.02.004--Not Available
Suicide attempt19.12.01.0040.000042%
Supraventricular tachycardia02.03.03.0120.000035%
Swelling08.01.03.0150.000091%Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.000060%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000015%Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.000255%
Systemic lupus erythematosus15.06.02.003; 10.04.03.004; 23.03.02.0060.000010%Not Available
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.0140.000032%Not Available
Telangiectasia24.03.03.003; 23.06.03.0010.000010%
Tension19.06.02.005--Not Available
Testicular atrophy21.13.01.001; 05.05.02.0040.000010%Not Available
Therapeutic response decreased08.06.01.016--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.0020.000027%
Toothache07.09.06.001--
Torsade de pointes02.03.04.0050.000025%Not Available
Toxic epidermal necrolysis12.03.01.015; 11.07.01.006; 10.01.01.006; 23.03.01.008--
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.0110.000020%
Urinary tract disorder20.08.01.0010.000025%Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vascular purpura24.07.06.011; 23.06.01.008; 01.01.04.007--Not Available
Vasculitis10.02.02.006; 24.12.04.027--
Vasculitis necrotising24.12.04.029; 10.02.02.008--Not Available
Ventricular extrasystoles02.03.04.0070.000010%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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