Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Histamine
Drug ID BADD_D01071
Description A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Indications and Usage Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Marketing Status Not Available
ATC Code L03AX14
DrugBank ID DB05381
KEGG ID D04444
MeSH ID D006632
PubChem ID 774
TTD Drug ID D04USC
NDC Product Code 63083-1522; 65044-9998; 81701-111
Synonyms Histamine | Peremin | Histamine Dihydrochloride | Histamine Hydrochloride | Ceplene
Chemical Information
Molecular Formula C5H9N3
CAS Registry Number 51-45-6
SMILES C1=C(NC=N1)CCN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.001--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injection site bruising24.07.06.017; 23.03.11.015; 08.02.03.042; 12.07.03.042--Not Available
Injection site dermatitis23.03.04.033; 12.07.03.041; 08.02.03.041--Not Available
Injection site erythema23.03.06.015; 12.07.03.001; 08.02.03.001--Not Available
Injection site fibrosis12.07.03.025; 08.02.03.025--Not Available
Injection site granuloma23.03.15.003; 12.07.03.003; 08.02.03.003--Not Available
Injection site haemorrhage24.07.01.010; 12.07.03.005; 08.02.03.005--Not Available
Injection site inflammation12.07.03.009; 08.02.03.008--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site pruritus08.02.03.013; 23.03.12.007; 12.07.03.014--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injection site urticaria23.04.02.003; 12.07.03.029; 10.01.06.003; 08.02.03.029--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
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