Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Glyburide
Drug ID BADD_D01030
Description Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin].[L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.[A183617] Glyburide was granted FDA approval on 1 May 1984.[L8117] A formulation with metformin was granted FDA approval on on 31 July 2000.[L8120]
Indications and Usage Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.
Marketing Status Prescription; Discontinued
ATC Code A10BB01
DrugBank ID DB01016
KEGG ID D00336
MeSH ID D005905
PubChem ID 3488
TTD Drug ID D05LYX
NDC Product Code 63187-667; 75834-204; 68071-5215; 63629-1393; 66267-103; 70934-855; 70934-409; 52817-121; 75834-203; 65862-318; 68382-656; 71209-009; 70934-715; 0093-9477; 0093-8344; 65862-029; 0121-0930; 0009-0352; 68382-657; 12579-056; 50090-3429; 0143-9920; 72241-040; 55289-606; 70518-1513; 0121-0931; 76333-155; 23155-056; 0115-1744; 53002-4170; 68382-658; 63629-2907; 65841-833; 12579-054; 68071-2589; 46438-0059; 68071-4142; 61919-330; 68071-4730; 0093-8343; 0009-3449; 65862-030; 68788-7970; 71335-0150; 42291-317; 0143-9918; 76333-154; 68071-2402; 63187-848; 50090-0495; 0143-9919; 55700-725; 0115-1742; 0093-8036; 72241-039; 0093-8035; 72241-038; 68071-5217; 0093-8342; 49452-3355; 23155-057; 52817-120; 71209-011; 70518-2695; 42291-316; 0121-0929; 65841-834; 43063-433; 70518-1646; 0093-9433; 68071-4695; 70934-569; 52817-122; 65862-028; 62147-0002; 63187-659; 50090-0494; 68071-5029; 68071-5030; 0093-8034; 50090-4215; 12828-0066; 71209-010; 61919-378; 0115-1743; 0093-9364; 50090-5776; 65841-832; 76333-156; 71335-0069; 70518-2644; 70518-1201; 12579-055; 43353-656; 75834-202; 43353-659; 0009-0341; 23155-058; 65691-0041
Synonyms Glyburide | Glybenclamide | Glibenclamide | Diabeta | Euglucon 5 | Neogluconin | HB-419 | HB 419 | HB419 | HB-420 | HB 420 | HB420 | Maninil | Micronase | Daonil | Euglucon N
Chemical Information
Molecular Formula C23H28ClN3O5S
CAS Registry Number 10238-21-8
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HaemolysisGlucose-6-phosphate 1-dehydrogenaseP11413T634848562390; 15126005; 2502894; 12610074; 15645702; 1760119; 3603644
ObesityATP-binding cassette sub-family C member 8Q09429Not Available9439807; 8955950; 9037388
ObesityATP-binding cassette sub-family C member 9Q63563Not Available9439807; 8955950; 9037388
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyponatraemia14.05.04.002--
Hypopituitarism05.03.02.001--
Hypotension24.06.03.002--
Hypotrichosis23.02.02.003--Not Available
Insulin C-peptide increased13.10.02.0110.000415%Not Available
Insulin resistance14.06.02.003; 05.06.02.0030.000623%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Lactic acidosis14.01.01.0020.000623%Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.000108%Not Available
Miosis17.02.11.002; 06.05.03.0030.000415%Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.000623%
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nephropathy20.05.03.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Photosensitivity reaction23.03.09.003--
Pneumonia22.07.01.003; 11.01.09.0030.000415%Not Available
Porphyria non-acute23.03.01.012; 14.14.01.004; 09.01.10.003; 03.08.01.004--Not Available
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rash morbilliform23.03.13.005--Not Available
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