Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gefitinib
Drug ID BADD_D01008
Description Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Indications and Usage For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Marketing Status Prescription; Discontinued
ATC Code L01EB01
DrugBank ID DB00317
KEGG ID D01977
MeSH ID D000077156
PubChem ID 123631
TTD Drug ID D09XZB
NDC Product Code 54245-1359; 65344-0029; 54893-0036; 63850-8070; 53104-7700; 73377-128; 0310-0482; 61200-002; 46708-880; 68554-0060
Synonyms Gefitinib | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide | Iressa | ZD1839 | ZD 1839
Chemical Information
Molecular Formula C22H24ClFN4O3
CAS Registry Number 184475-35-2
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fracture15.08.02.001; 12.04.02.0010.001598%
Gait disturbance17.02.05.016; 08.01.02.002--
Gamma-glutamyltransferase increased13.03.01.0110.002131%
Gastric cancer16.13.03.001; 07.21.02.0010.000208%Not Available
Gastric ulcer07.04.03.0020.000799%
Gastrooesophageal reflux disease07.02.02.0030.000533%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal necrosis24.04.08.006; 07.15.01.0030.000533%
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.001--Not Available
Haematemesis07.12.02.002; 24.07.02.0110.000208%Not Available
Haematuria20.02.01.006; 24.07.01.047--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis22.02.03.004; 02.01.02.006; 24.07.01.0060.001598%Not Available
Haemothorax24.07.01.008; 22.05.02.001; 12.01.03.0020.000533%
Headache17.14.01.001--
Hemiparesis17.01.04.0010.000533%
Hepatic cyst09.01.08.008; 16.06.02.0010.000533%Not Available
Hepatic failure09.01.03.0020.000278%
Hepatic function abnormal09.01.02.0010.003730%Not Available
Hepatitis09.01.07.0040.001066%Not Available
Hepatocellular injury09.01.07.0080.000533%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.001332%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000533%
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypokalaemia14.05.03.0020.000533%
Hypomagnesaemia14.04.02.001--
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