Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gefitinib
Drug ID BADD_D01008
Description Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Indications and Usage For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Marketing Status Prescription; Discontinued
ATC Code L01EB01
DrugBank ID DB00317
KEGG ID D01977
MeSH ID D000077156
PubChem ID 123631
TTD Drug ID D09XZB
NDC Product Code 54245-1359; 65344-0029; 54893-0036; 63850-8070; 53104-7700; 73377-128; 0310-0482; 61200-002; 46708-880; 68554-0060
Synonyms Gefitinib | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide | Iressa | ZD1839 | ZD 1839
Chemical Information
Molecular Formula C22H24ClFN4O3
CAS Registry Number 184475-35-2
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depression19.15.01.001--
Dermatitis23.03.04.0020.000533%Not Available
Dermatitis acneiform23.02.01.0040.001865%
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.0010.009058%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug hypersensitivity10.01.01.001--Not Available
Drug interaction08.06.03.001--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dry skin23.03.03.0010.001598%
Duodenal ulcer07.04.02.0020.000533%
Dysarthria19.19.03.001; 17.02.08.0010.000533%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.001332%
Dyspnoea22.02.01.004; 02.01.03.002--
Electrocardiogram QT prolonged13.14.05.004--
Eosinophil count increased13.01.06.0040.000533%Not Available
Epilepsy17.12.03.0020.000533%Not Available
Epistaxis24.07.01.005; 22.04.03.0010.001598%
Erythema23.03.06.0010.001865%Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Eye disorder06.08.03.0010.000533%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001--Not Available
Eye pain06.08.03.002--
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.001332%
Femoral neck fracture15.08.03.002; 12.04.01.0020.000533%Not Available
Femur fracture15.08.03.003; 12.04.01.0030.001332%Not Available
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 10 Pages