Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluticasone propionate
Drug ID BADD_D00947
Description Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Indications and Usage Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Marketing Status Prescription; OTC; Discontinued
ATC Code D07AC17; R01AD08; R03BA05
DrugBank ID DB00588
KEGG ID D01708
MeSH ID D000068298
PubChem ID 444036
TTD Drug ID D0LC6K
NDC Product Code 70518-1655; 65089-0033; 53943-006; 68071-4156; 15308-0200; 46122-338; 37808-205; 0363-0881; 11673-262; 60505-0847; 21130-122; 53002-1294; 63868-656; 50383-968; 50909-5175; 50090-0968; 0363-0652; 0173-0600; 70518-2930; 21130-680; 0363-5010; 63654-380; 55301-506; 41520-703; 21130-089; 50594-319; 41250-634; 68788-6926; 41250-933; 63629-8659; 71143-375; 50090-1978; 60505-0829; 50090-2267; 56062-107; 0173-0718; 11822-0901; 53873-079; 60505-6134; 0113-0285; 72559-002; 36800-222; 68196-208; 49035-362; 22552-0043; 80267-000; 0173-0719; 50090-0916; 69842-900; 69842-765; 38779-2760; 49348-182; 81522-005; 59310-200; 11673-220; 71205-443; 64918-1600; 41163-023; 0173-0602; 60505-0955; 30142-301; 55910-773; 68016-723; 64918-1118; 61919-930; 64525-8000; 63190-0520; 55700-714; 30142-258; 68196-210; 46122-684; 0713-0631; 50090-4410; 64918-1700; 59310-311; 60505-6167; 30142-767; 69256-061; 50090-2880; 50383-700; 0363-0024; 63629-8661; 53104-7531; 70518-1223; 68788-9678; 81522-002; 63868-400; 55700-680; 45802-222; 0135-0582; 53002-7692; 68391-133; 64525-6560; 53943-500; 50090-0934; 50090-2557; 60505-6205; 45802-221; 11822-7005; 45802-441; 63187-021; 49035-060; 55315-800; 68462-427; 64024-007; 62011-0269; 58175-0361; 37835-997; 53002-1310; 0713-0729; 72189-004; 11822-1177; 63940-501; 52482-001; 59310-525; 41520-553; 11822-5000; 63981-001; 60429-195; 50090-3513; 0173-0601; 72288-333; 63379-001; 49035-200; 68071-2582; 0168-0434; 50090-0910; 68788-7788; 11673-388; 69842-770; 68998-600; 46122-386; 63187-638; 63629-8662; 11822-7003; 36800-572; 16812-005; 59310-505; 0173-0720; 11673-103; 0536-1183; 37808-340; 55319-019; 49076-5501; 60505-6201; 10337-434; 63629-8660; 63187-959; 53002-7691; 52221-106; 55315-825; 68071-4868; 63187-957; 36800-128; 50090-1245; 0168-0332; 51672-4095; 11822-5001; 0113-7117; 72288-119; 59310-515; 53873-078; 0054-3270; 55910-607; 69842-757; 50090-3679; 49035-063; 68071-1638; 80159-201; 0113-0028; 68788-7658; 63629-8658; 69168-380; 55018-301; 63187-806; 50090-1187; 70000-0110; 0363-5012; 76420-106; 0135-0576; 60432-264; 41163-100; 59310-114; 0713-0632; 53002-7690; 69842-228; 79903-071; 68788-9925; 63629-8663; 51927-0013; 69306-016; 50090-3803; 50090-2484; 51552-1310; 76162-656
Synonyms Fluticasone | Flonase | Flovent HFA | HFA, Flovent | Cutivate | Fluticasone Propionate | Propionate, Fluticasone | Flixonase | Flixotide | Flovent
Chemical Information
Molecular Formula C25H31F3O5S
CAS Registry Number 80474-14-2
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchitis22.07.01.001; 11.01.09.0010.000774%
Bronchospasm22.03.01.004; 10.01.03.0120.000332%
Bronchospasm paradoxical22.03.01.0060.000221%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000553%Not Available
C-reactive protein increased13.09.01.0070.000221%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000058%Not Available
Carpal tunnel syndrome17.09.02.0010.000221%Not Available
Cataract06.06.01.0010.000332%
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.0010.000553%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000774%Not Available
Chills15.05.03.016; 08.01.09.0010.000221%
Choking22.02.05.0010.000332%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000202%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.0010.001991%
Crohn's disease10.02.01.005; 07.08.01.0150.000221%Not Available
Crying17.02.05.013; 12.02.11.001; 08.01.03.005; 19.04.02.0020.000553%Not Available
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.0010.000885%Not Available
Cushingoid24.08.02.004; 19.07.03.001; 14.11.01.006; 05.01.01.0020.000221%
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis acneiform23.02.01.004--
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.000332%Not Available
Diarrhoea07.02.01.001--
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