Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluorouracil
Drug ID BADD_D00931
Description A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Indications and Usage For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Marketing Status Prescription; Discontinued
ATC Code L01BC02
DrugBank ID DB00544
KEGG ID D00584
MeSH ID D005472
PubChem ID 3385
TTD Drug ID D05LEO
NDC Product Code 63323-117; 0378-8078; 51672-4062; 16714-178; 70700-189; 51862-362; 51672-4118; 70700-186; 50090-4264; 38779-0025; 51672-4063; 0378-4791; 68001-524; 25021-215; 68001-266; 62049-185; 38779-3185; 16729-276; 68001-525; 0187-3204; 68083-269; 68083-293; 51927-1085; 68083-270; 66530-249; 28105-421; 16110-812; 68083-292; 70700-187; 0187-5200; 70700-188; 59348-0055; 12070-0002; 49452-3175; 16729-542; 0395-8080; 62991-1486
Synonyms Fluorouracil | 5FU | 5-FU | 5-Fluorouracil | 5 Fluorouracil | Fluoruracil | 5-FU Lederle | 5 FU Lederle | 5-FU Medac | 5 FU Medac | 5-HU Hexal | 5 HU Hexal | Adrucil | Carac | Efudix | Fluoro-Uracile ICN | Fluoro Uracile ICN | Efudex | Fluoroplex | Flurodex | Fluorouracil Mononitrate | Fluorouracil Monopotassium Salt | Fluorouracil Monosodium Salt | Fluorouracil Potassium Salt | Fluorouracil-GRY | Fluorouracil GRY | Fluorouracile Dakota | Dakota, Fluorouracile | Fluorouracilo Ferrer Far | Fluracedyl | Haemato-FU | Haemato FU | Neofluor | Onkofluor | Ribofluor | 5-Fluorouracil-Biosyn | 5 Fluorouracil Biosyn
Chemical Information
Molecular Formula C4H3FN2O2
CAS Registry Number 51-21-8
SMILES C1=C(C(=O)NC(=O)N1)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisSoluble TNF receptor IIP68636Not Available14614330; 15546879; 10583368
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal discomfort15.03.04.001--Not Available
Febrile bone marrow aplasia01.03.03.007; 08.05.02.0050.000859%Not Available
Cerebral haematoma24.07.04.006; 17.08.01.0140.000941%Not Available
Skin burning sensation17.02.06.009; 23.03.03.0210.002352%Not Available
Transaminases increased13.03.01.0150.007997%Not Available
Haemorrhage24.07.01.002--Not Available
Congestive cardiomyopathy02.04.01.0030.002352%Not Available
Cutaneous lupus erythematosus15.06.02.007; 10.04.03.007; 23.03.02.0080.001882%Not Available
Gaze palsy17.02.05.044; 06.05.02.0140.001411%Not Available
Gastrointestinal ulcer haemorrhage24.07.02.023; 07.04.04.006--Not Available
Temperature intolerance08.01.09.0220.000941%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.000941%Not Available
Anticonvulsant drug level increased13.17.01.0090.000941%Not Available
Toxic skin eruption23.03.05.003; 10.01.01.0080.001411%Not Available
Staphylococcal infection11.02.05.0020.001411%Not Available
Lung neoplasm malignant16.19.02.001; 22.08.01.001--Not Available
Haemobilia24.07.01.049; 09.01.08.0090.000941%Not Available
Gastrointestinal toxicity07.08.03.006; 12.03.01.0190.005175%Not Available
Skin toxicity23.03.03.032; 12.03.01.0200.001411%Not Available
Blood alkaline phosphatase increased13.04.02.0040.001882%
Drug resistance08.06.01.005--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.003293%
Abdominal abscess11.01.07.006; 07.19.02.0020.000941%Not Available
Electrocardiogram change13.14.05.014--Not Available
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Embolism24.01.01.0090.000245%
Haematotoxicity12.03.01.025; 01.05.01.0070.005175%Not Available
Infestation11.09.01.001; 23.09.05.001--Not Available
Inflammation08.01.05.0070.004234%Not Available
Ischaemia24.04.02.0040.000941%Not Available
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