Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluocinolone acetonide
Drug ID BADD_D00924
Description Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.[T357] It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices.[T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and approved by FDA in May 2016.[L4676]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also for the treatment of chronic non-infectious uveitis affecting the posterior segment of the eye (Retisert).
Marketing Status Prescription; Discontinued
ATC Code C05AA10; D07AC04; S01BA15; S02BA08
DrugBank ID DB00591
KEGG ID D01825
MeSH ID D005446
PubChem ID 6215
TTD Drug ID D02QJH
NDC Product Code 64980-331; 63629-8655; 51927-0150; 68462-185; 0299-5500; 46439-8709; 64980-330; 51672-1365; 10135-670; 43538-911; 70752-159; 68791-101; 24208-416; 65162-704; 53183-0261; 49452-3156; 68462-591; 65162-703; 43538-900; 0168-0064; 71879-136; 65162-702; 43538-920; 71161-134; 0713-0709; 45802-887; 68791-102; 45802-485; 0395-8243; 43386-069; 43538-910; 71428-002; 70752-158; 0713-0223; 76420-163; 45802-009; 43538-921; 39328-079; 70752-156; 43538-901; 51672-1357; 68611-190; 0713-0224; 68791-103; 63629-8656; 51672-1356; 38779-0022; 68462-590
Synonyms Fluocinolone Acetonide | Acetonide, Fluocinolone | Fluortriamcinolone Acetonide | Acetonide, Fluortriamcinolone | Flurosyn | Jellin | Jellisoft | Synalar | Synalar-HP | Synalar HP | Synemol | Synamol | Alvadermo | Capex | Co-Fluocin | Co Fluocin | Cortiespec | Derma-Smooth FS | Derma Smooth FS | Flucinar | Fluocid | Fluodermo | Fluonid | Fluotrex | Flusolgen | Gelidina
Chemical Information
Molecular Formula C24H30F2O6
CAS Registry Number 67-73-2
SMILES CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness postural02.01.02.005; 24.06.02.008; 17.02.05.004--Not Available
Dry eye06.08.02.001--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Ear disorder04.03.01.001--Not Available
Ear infection04.03.01.006; 11.01.05.001--Not Available
Ear pain04.03.01.003--
Eczema23.03.04.006--
Endophthalmitis11.01.06.003; 06.04.05.0090.007658%
Erythema23.03.06.001--Not Available
Eye discharge06.04.05.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.001532%Not Available
Eye infection11.01.06.001; 06.04.05.007--
Eye inflammation06.04.05.0020.001532%Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.0020.004595%
Eye swelling06.08.03.003--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Folliculitis23.09.04.007; 11.01.12.018--
Fungal skin infection23.09.02.001; 11.03.05.002--Not Available
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.0020.006892%
Headache17.14.01.001--
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Hypersensitivity10.01.03.003--
Hypertrichosis23.02.04.002--
Hyphaema24.07.05.004; 12.01.04.007; 06.07.04.001--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
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