Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fludarabine phosphate
Drug ID BADD_D00915
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Prescription; Discontinued
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D01907
MeSH ID C042382
PubChem ID 30751
TTD Drug ID D0TO2R
NDC Product Code 45963-621; 53183-7841; 59923-604; 51916-310; 33656-0015; 63323-192; 24201-237; 25021-242; 45963-609; 58623-0043; 59605-7136
Synonyms fludarabine phosphate | fludarabine 5'-monophosphate | 9 beta-D-arabinofuranosyl-2-fluoroadenine monophosphate | fludarabine monophosphate | FaraAMP | fluoro-ara-AMP | 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- | F-ara-AMP | NSC 312887 | NSC-312887 | Beneflur | Fludara
Chemical Information
Molecular Formula C10H13FN5O7P
CAS Registry Number 75607-67-9
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Hypoaesthesia17.02.06.023--Not Available
Hypocalcaemia14.04.01.004--
Hypoxia22.02.02.003--
Infection11.01.08.002--Not Available
Interstitial lung disease10.02.01.033; 22.01.02.003--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Metabolic acidosis14.01.01.003--Not Available
Mucosal inflammation08.01.06.002--Not Available
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity12.03.01.011; 17.02.10.002--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.010--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oesophagitis07.08.05.001--
Opportunistic infection11.01.08.007--Not Available
Optic neuritis06.04.08.002; 17.04.05.001; 10.04.10.002--Not Available
Osteoporosis15.02.03.002; 14.04.04.002--
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
The 3th Page    First    Pre   3 4 5 6    Next   Last    Total 6 Pages