Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fentanyl citrate
Drug ID BADD_D00880
Description Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.[A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.[L6751] Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Indications and Usage For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.
Marketing Status Prescription; Discontinued
ATC Code N01AH01; N02AB03
DrugBank ID DB00813
KEGG ID D01399
MeSH ID D005283
PubChem ID 13810
TTD Drug ID D0E1WI
NDC Product Code 0406-9202; 64181-0007; 0641-6026; 0641-6247; 0406-9216; 63459-516; 63275-5100; 51552-0687; 0641-6028; 0641-6030; 59116-3281; 63323-806; 63459-512; 51862-636; 0641-6027; 0641-6025; 0093-7865; 51862-634; 63323-817; 0093-7869; 63323-808; 49452-0032; 51862-635; 63459-506; 51927-0042; 0406-9208; 0406-1344; 0409-1276; 42358-200; 0406-1130; 38779-1756; 59116-3282; 59116-3280; 0641-6024; 0093-7867; 62991-1405; 0641-6029; 72572-171; 0093-7868; 0409-9094; 61960-9500; 17478-030; 0409-9093; 0406-9204; 63459-508; 0406-9206; 51862-637; 63459-504; 81371-2010; 0406-9212; 49812-0001; 0406-1333; 0093-7870; 0406-1205; 63459-502; 72572-170; 82393-118; 51862-638; 72572-172; 0093-7866; 17478-031
Synonyms Fentanyl | Phentanyl | Fentanest | Fentanyl Citrate | R-4263 | R 4263 | R4263 | Sublimaze | Transmucosal Oral Fentanyl Citrate | Duragesic | Durogesic | Fentora
Chemical Information
Molecular Formula C28H36N2O8
CAS Registry Number 990-73-8
SMILES CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug tolerance increasedMu-type opioid receptorP35372T47768Not Available
Drug tolerance increasedAdenylate cyclase type 1Q08828T63609Not Available
PainAbscisic acid-inducible protein kinaseQ02066Not AvailableNot Available
PainOpioid growth factor receptorQ9NZT2T13741Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.01.02.003--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Parosmia17.04.04.002; 22.04.03.007--Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006--Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Peripheral vascular disorder24.03.01.003--Not Available
Peroneal nerve palsy17.09.02.003--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumothorax22.05.02.003--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Pyelonephritis20.01.09.001; 11.01.14.002--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.005--Not Available
Renal pain20.02.03.003--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
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