Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Famotidine
Drug ID BADD_D00869
Description Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children.[L11166] Compared to other H2 receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory disease, famotidine was about 20 to 50 times more potent at inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a weight basis.[A189462] Famotidine is used in various over-the-counter and off-label uses.[L11166] While oral formulations of famotidine are more commonly used, the intravenous solution of the drug is available for use in hospital settings.[L11142]
Indications and Usage For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA03
DrugBank ID DB00927
KEGG ID D00318
MeSH ID D015738
PubChem ID 3325
TTD Drug ID D0K0OZ
NDC Product Code 63629-2782; 50090-1432; 67457-433; 58118-0859; 69842-063; 71205-257; 41250-712; 72288-141; 61442-122; 49035-589; 70934-510; 65841-135; 69842-928; 51927-3408; 72036-026; 36800-194; 55910-141; 49452-3038; 55289-765; 0113-0141; 11673-414; 70934-780; 59779-194; 50090-3305; 62332-001; 55111-118; 70860-751; 57896-769; 71335-0231; 68071-3181; 41163-313; 64679-374; 60687-595; 63323-739; 62332-002; 55111-012; 53002-3199; 55111-396; 67296-1795; 63187-999; 30142-194; 60760-070; 63323-738; 0113-0194; 68071-4197; 16714-244; 68788-7191; 80267-194; 51552-1583; 0113-7194; 65862-860; 36800-141; 72189-141; 72865-215; 63868-583; 11673-061; 53002-2199; 69842-924; 59779-141; 46708-294; 61442-121; 0172-5728; 49711-0098; 72789-027; 63629-7661; 63868-563; 43602-511; 68016-801; 68382-444; 50090-5241; 54257-802; 69842-267; 70000-0539; 72606-510; 57896-767; 52904-926; 71610-399; 63187-908; 49348-817; 68016-010; 50090-1045; 54257-180; 71713-701; 71205-276; 66715-9748; 53943-100; 12836-0307; 0641-6023; 0641-6021; 70518-1877; 53943-101; 51655-312; 67457-448; 55315-435; 70954-316; 68016-800; 68788-6859; 67296-1383; 63739-645; 70000-0048; 0615-8301; 68001-241; 69842-087; 67835-5012; 67296-1776; 69842-266; 70518-0163; 43063-533; 46708-293; 0363-5300; 61919-281; 50090-4389; 70518-1001; 68196-121; 71610-470; 49035-650; 67296-1121; 43602-501; 72189-207; 11673-031; 21130-777; 55111-120; 41250-493; 58602-828; 55910-194; 0363-1899; 11822-0194; 71872-7220; 31722-018; 43063-086; 0363-0141; 71205-637; 45865-881; 50268-304; 72865-214; 68391-300; 49035-118; 68071-3305; 68016-097; 0641-6022; 62011-0143; 72606-509; 72288-329; 63187-723; 55111-119; 41167-0360; 58602-829; 70120-063; 0536-1298; 0187-4440; 70000-0503; 70518-3301; 63629-2014; 0338-5197; 41520-707; 53002-6670; 50090-3888; 68016-096; 50268-303; 0904-5780; 49348-128; 63868-562; 68001-494; 68180-150; 68645-594; 63981-194; 65862-859; 59651-112; 60760-327; 43602-502; 58602-706; 73377-072; 62011-0142; 72640-018; 71872-7235; 68196-225; 16837-872; 71205-535; 70518-0460; 11822-0141; 63187-129; 70000-0049; 45541-1175; 41163-001; 71610-389; 65649-211; 0363-0701; 53069-0570; 81522-141; 31722-017; 64679-972; 43386-500; 66406-0101; 0904-7193; 68001-398; 43063-696; 63629-7926; 49035-507; 37808-301; 46122-168; 56062-194; 70860-753; 71205-634; 67835-0021; 63629-2015; 69256-141; 71335-1950; 70518-1415; 58602-859; 49035-396; 43063-695; 81842-604; 42291-281; 21130-249; 60429-721; 53002-1199; 50383-913; 37808-042; 46122-394; 63868-584; 24385-385; 68071-3201; 51407-452; 0615-4582; 63629-1014; 0172-5729; 68645-140; 70860-752; 50594-002; 0904-5529; 71335-0409; 41520-901; 41167-0361; 69575-4050; 16837-855; 49999-230; 66406-0100; 72375-0003; 53069-0210; 70934-819; 68788-7922; 70120-064; 43598-960; 43602-602; 0187-4420; 58602-705; 61919-236; 30142-141; 42291-282; 68788-7853; 63629-7321; 67457-457; 56062-141; 70934-814; 51662-1375; 68071-2306; 68001-397; 65977-0125; 72288-194; 59651-053; 0113-7141; 46708-867; 72288-151; 63629-1013; 68016-008; 70518-1341; 71335-1520; 55319-377; 38779-0655; 68196-061; 55154-6843; 67296-0963; 49035-505; 68001-240; 70518-0461; 71335-0370; 43598-824; 0363-4400
Synonyms Famotidine | YM-11170 | YM 11170 | YM11170 | Pepcid | Famotidine Hydrochloride | MK-208 | MK 208 | MK208
Chemical Information
Molecular Formula C8H15N7O2S3
CAS Registry Number 76824-35-6
SMILES C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bone marrow failureInterleukin-3P08700Not Available1623058; 1692489; 8542941; 1709711; 8677737; 7686503; 7693032; 7694721; 1638026; 1693298; 7694867; 2649515; 1688720; 1704083; 2463929; 8112428; 1697091; 1697091; 2455571; 3040231; 7533580
Bone marrow failureGranulocyte-macrophage colony-stimulating factorP04141T740021623058; 1692489; 8542941; 1709711; 8677737; 7686503; 7693032; 7694721; 1638026; 1693298; 7694867; 2649515; 1688720; 1704083; 2463929; 8112428; 1697091; 1697091; 2455571; 3040231; 7533580
Bone marrow failureGranulocyte colony-stimulating factor receptorQ99062T989131623058; 1692489; 8542941; 1709711; 8677737; 7686503; 7693032; 7694721; 1638026; 1693298; 7694867; 2649515; 1688720; 1704083; 2463929; 8112428; 1697091; 1697091; 2455571; 3040231; 7533580
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate increased13.14.04.0020.000262%Not Available
Hepatic function abnormal09.01.02.0010.000656%Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis fulminant09.01.07.007; 11.07.01.0030.000068%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000262%
Hyperglycaemia14.06.02.002; 05.06.02.0020.000262%
Hypersensitivity10.01.03.0030.000787%
Hypertension24.08.02.0010.000394%
Hypocalcaemia14.04.01.0040.001575%
Hypomagnesaemia14.04.02.0010.001444%
Hypoparathyroidism14.04.01.007; 12.02.15.001; 05.04.02.0010.001312%
Hypotension24.06.03.002--
Hypotrichosis23.02.02.003--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.0010.000262%Not Available
Influenza like illness08.01.03.010--
Injection site irritation12.07.03.027; 08.02.03.027--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.000262%Not Available
Intestinal obstruction07.13.01.0020.000525%Not Available
Irritability08.01.03.011; 19.04.02.013--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000525%Not Available
Jaundice cholestatic09.01.01.005--Not Available
Laceration12.01.06.006; 23.03.11.0040.000262%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000262%
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000262%Not Available
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