Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etodolac
Drug ID BADD_D00850
Description Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Indications and Usage For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
Marketing Status Prescription; Discontinued
ATC Code M01AB08
DrugBank ID DB00749
KEGG ID D00315
MeSH ID D017308
PubChem ID 3308
TTD Drug ID D0N1WU
NDC Product Code 51655-423; 60760-378; 17373-1086; 61919-251; 71335-0126; 43353-918; 51672-4051; 63629-1935; 63187-374; 43063-834; 0185-0687; 55700-592; 63629-8805; 57451-1161; 60429-312; 71335-0982; 50090-3974; 60505-0040; 43353-749; 43063-578; 43063-856; 70518-3116; 55700-757; 60429-244; 60429-315; 43353-753; 71335-0399; 61919-092; 71205-467; 51672-4052; 66267-575; 63187-796; 60760-552; 71335-0602; 68788-7315; 76385-118; 68382-272; 61919-784; 68382-271; 70518-3163; 60429-314; 43353-752; 62559-251; 50090-3963; 68382-273; 60505-0039; 0093-1118; 63187-736; 60429-313; 69238-1342; 63629-8598; 65841-779; 42291-405; 43063-671; 62559-250; 63187-793; 50090-0613; 50090-1789; 42291-404; 42799-111; 80425-0140; 35356-711; 63629-3641; 51672-4018; 70934-282; 63629-1936; 43353-294; 60429-311; 69238-1343; 51672-4053; 60429-243; 50090-4053; 65841-778; 71335-1958; 68788-7300; 80425-0181; 60505-0041; 51672-4036; 80425-0126; 12658-0580; 16714-499; 65841-777; 0093-1122; 60760-298; 51672-4016; 50090-2133; 71205-140; 16714-498; 16714-497; 51672-4017; 50090-1790; 71335-1230; 67296-1271; 69306-020; 17373-1087; 58793-010; 42799-112; 61919-858; 0185-0675; 67628-1001; 0093-7172; 60505-0102; 76385-119
Synonyms Etodolac | Etodolic Acid | Etodolac, (+-)-Isomer | Etodolac, (-)-Isomer | Etodolac, (S)-Isomer | Ultradol | Etodolac, Monosodium Salt, (+-) Isomer | Etodolac, Monosodium Salt, (S)-Isomer | Lodine | Ramodar | AY-24,236 | AY 24,236 | AY-24236 | AY 24236 | Etodolac, Monosodium Salt
Chemical Information
Molecular Formula C17H21NO3
CAS Registry Number 41340-25-4
SMILES CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Encephalopathy17.13.02.0010.001484%
Enterocolitis07.08.03.0030.000989%
Eosinophilia01.02.04.001--
Eructation07.01.02.003--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastric haemorrhage24.07.02.007; 07.12.01.0010.002473%
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.000989%Not Available
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001--Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000989%Not Available
Haematochezia24.07.02.012; 07.12.02.003--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.000989%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Headache17.14.01.0010.000989%
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.001978%Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.0040.000989%Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hepatitis fulminant11.07.01.003; 09.01.07.007--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
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