Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etidronic acid
Drug ID BADD_D00849
Description Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid].[A203111] Etidronic acid was granted FDA approval on 1 September 1977.[L13901]
Indications and Usage For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
Marketing Status Prescription; Discontinued
ATC Code M05BA01
DrugBank ID DB01077
KEGG ID D02373
MeSH ID D012968
PubChem ID 3305
TTD Drug ID D00NNC
NDC Product Code Not Available
Synonyms Etidronic Acid | (1-hydroxyethylene)diphosphonic acid | Hydroxyethylidene Diphosphonic Acid | Diphosphonic Acid, Hydroxyethylidene | Etidronate | 1-Hydroxyethane-1,1-Diphosphonate | 1 Hydroxyethane 1,1 Diphosphonate | 1-Hydroxyethylidene-1,1-Bisphosphonate | 1 Hydroxyethylidene 1,1 Bisphosphonate | EHDP | 1,1-hydroxyethylenediphosphonate | 1,1 hydroxyethylenediphosphonate | HEDP | Hydroxyethanediphosphonate | Ethanehydroxyphosphate | Ethanehydroxydiphosphonate | Etidronate Disodium | Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt | Sodium Etidronate | Etidronate, Sodium | Disodium 1-Hydroxyethylene Diphosphonate | 1-Hydroxyethylene Diphosphonate, Disodium | Diphosphonate, Disodium 1-Hydroxyethylene | Disodium 1 Hydroxyethylene Diphosphonate | Disodium Etidronate | Etidronate, Disodium | HEDSPA | Dicalcium Etidronate | Etidronate, Dicalcium | Dicalcium EHDP | EHDP, Dicalcium | Xidifon | Xydiphone | Xidiphon | Didronel | Etidronate, Tetrapotassium Salt | Salt Etidronate, Tetrapotassium | Tetrapotassium Salt Etidronate | (1-hydroxyethylene)diphosphonic acid, Tetrapotassium Salt
Chemical Information
Molecular Formula C2H8O7P2
CAS Registry Number 2809-21-4
SMILES CC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infection11.01.08.002--Not Available
Leukaemia16.01.03.001; 01.10.03.001--
Leukopenia01.02.02.001--Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Oesophagitis07.08.05.001--
Osteoarthritis15.01.04.001--Not Available
Osteolysis15.02.03.008; 14.04.04.006--Not Available
Osteomalacia15.02.03.001; 14.04.04.001; 20.01.01.002--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Osteoporosis15.02.03.002; 14.04.04.002--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash follicular23.03.10.001--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.004--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Extraskeletal ossification15.02.04.021--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Osteonecrosis of jaw24.04.05.005; 15.02.04.010--
Oral disorder07.05.01.005--Not Available
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