Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol hydrochloride
Drug ID BADD_D00842
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage For use, as an adjunct, in the treatment of pulmonary tuberculosis.
Marketing Status Prescription; Discontinued
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D00878
MeSH ID D004977
PubChem ID 14051
TTD Drug ID D08QME
NDC Product Code 68850-010; 68180-281; 50090-5142; 50090-2607; 42806-102; 68180-280; 70518-2691; 68850-012; 50090-5140; 66406-0224; 65691-0014; 42806-101; 70518-2966; 50090-2337; 50090-3948; 68084-280; 54879-001; 54879-002
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H26Cl2N2O2
CAS Registry Number 1070-11-7
SMILES CCC(CO)NCCNC(CC)CO.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Arthralgia15.01.02.001--
Blindness17.17.01.003; 06.02.02.001--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Colour blindness06.02.09.001; 03.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Gout15.01.06.001; 14.09.01.001--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
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