Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol
Drug ID BADD_D00841
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage For use, as an adjunct, in the treatment of pulmonary tuberculosis.
Marketing Status Prescription; Discontinued
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D07925
MeSH ID D004977
PubChem ID 14052
TTD Drug ID D08QME
NDC Product Code 60592-243
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H24N2O2
CAS Registry Number 74-55-5
SMILES CCC(CO)NCCNC(CC)CO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.0040.004591%Not Available
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.004591%
Hypothyroidism14.11.01.012; 05.02.03.0010.004591%
Leukopenia01.02.02.001--Not Available
Lung infiltration22.01.02.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.0030.004591%
Myocarditis02.04.03.001--
Nausea07.01.07.0010.009182%
Nephritis20.05.02.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.0020.004591%Not Available
Paraesthesia17.02.06.005--
Pericarditis02.06.02.001--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.01.01.0050.001198%Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Refraction disorder06.02.04.004--Not Available
Sensory loss17.02.07.007--Not Available
Stevens-Johnson syndrome12.03.01.014; 23.03.01.007; 11.07.01.005; 10.01.03.020--
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis11.07.01.006; 10.01.01.006; 23.03.01.008; 12.03.01.015--
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced17.17.01.011; 06.02.03.001--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
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