| Drug Name |
Escitalopram |
| Drug ID |
BADD_D00809 |
| Description |
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class.[A185726] Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822] |
| Indications and Usage |
Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients. |
| Marketing Status |
Prescription |
| ATC Code |
N06AB10 |
| DrugBank ID |
DB01175
|
| KEGG ID |
D07913
|
| MeSH ID |
D000089983
|
| PubChem ID |
146570
|
| TTD Drug ID |
D08RBC
|
| NDC Product Code |
68071-2051; 68071-2035; 51655-284; 68071-4984; 68071-5248; 70518-2472; 65162-705; 42708-023; 70518-1110; 0456-2010; 63187-281; 71610-425; 61919-652; 63187-217; 50090-3331; 16729-168; 55700-847; 69097-849; 45865-699; 76282-249; 71335-1002; 0456-2005; 43547-281; 67296-1421; 0615-8349; 68001-455; 70518-2597; 63629-8241; 70518-3151; 68071-4985; 67296-1200; 33342-053; 51655-449; 53002-1438; 70934-112; 70771-1146; 68788-7510; 68788-7559; 16729-170; 0615-8348; 70518-1876; 70518-2317; 43063-661; 70518-2430; 71335-1307; 43547-282; 50090-4915; 70771-1147; 55700-818; 0615-8366; 68001-456; 71335-1571; 16729-169; 69097-848; 71335-1187; 70518-1805; 70518-1785; 67296-1689; 68645-520; 60760-393; 53002-2438; 50090-4363; 76282-251; 71205-344; 71335-1241; 50090-1930; 60760-170; 0615-8365; 68788-7461; 42708-022; 72789-194; 54838-551; 76282-250; 68788-7912; 0456-2020; 69097-847; 68001-454; 68645-519; 50090-5312; 67296-1597; 71205-325; 53002-1453; 43547-280; 71335-1030; 0615-8350; 68071-3069; 50090-2196; 67296-1408; 71610-534; 70771-1145; 71335-2058 |
| Synonyms |
Escitalopram | Escitalopram Oxalate | Lexapro |
