Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eprosartan mesylate
Drug ID BADD_D00791
Description Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Indications and Usage For the management of hypertension alone or in combination with other classes of antihypertensive agents. Also used as a first-line agent in the treatment of diabetic nephropathy, as well as a second-line agent in the treatment of congestive heart failure (only in those intolerant of ACE inhibitors).
Marketing Status Not Available
ATC Code C09CA02
DrugBank ID DB00876
KEGG ID D02082
MeSH ID C401803
PubChem ID 5282474
TTD Drug ID Not Available
NDC Product Code 65372-1142; 64220-108; 50370-0020; 53747-021
Synonyms eprosartan mesylate dihydrate | epro-sartan mesylate dihydrate
Chemical Information
Molecular Formula C24H28N2O7S2
CAS Registry Number 144143-96-4
SMILES CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O.CS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oesophagitis07.08.05.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Otitis externa11.01.05.003; 04.01.02.001--
Otitis media04.05.01.001; 11.01.05.004--
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Periodontitis11.01.04.012; 07.09.01.002--Not Available
Peripheral ischaemia24.04.03.002--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Purpura01.01.04.003; 24.07.06.005; 23.06.01.004--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rhinitis22.07.03.006; 11.01.13.004--
Somnolence17.02.04.006; 19.02.05.003--
Tachycardia02.03.02.007--Not Available
Tendonitis15.07.01.003; 12.01.07.007--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Toothache07.09.06.001--
Tremor17.01.06.002--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
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