Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Entecavir
Drug ID BADD_D00774
Description Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
Indications and Usage For the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Marketing Status Prescription
ATC Code J05AF10
DrugBank ID DB00442
KEGG ID D04008
MeSH ID C413685
PubChem ID 135398508
TTD Drug ID D0KR2J
NDC Product Code 42291-261; 31722-833; 69097-425; 60050-057; 43547-437; 16729-389; 60687-216; 51991-895; 42291-262; 0003-1614; 42806-659; 65862-842; 50268-289; 71921-194; 0003-1611; 63285-888; 63285-887; 68382-921; 65862-798; 70771-1020; 42806-658; 51407-065; 51991-896; 16714-718; 68382-920; 16729-388; 71921-195; 62227-101; 53104-7692; 31722-834; 16714-717; 65862-841; 0003-1612; 13612-0020; 70771-1019; 65977-0086; 62227-102; 69097-426; 51407-064; 17381-031; 66406-0331; 60050-077; 76397-001; 65162-446; 65162-449; 43547-436
Synonyms entecavir | Baraclude
Chemical Information
Molecular Formula C12H15N5O3
CAS Registry Number 142217-69-4
SMILES C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoglycaemia05.06.03.001; 14.06.03.0010.014982%
Hypophosphataemia14.04.03.0010.014982%
Ileus07.13.01.0010.089892%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Infertility21.03.02.0010.014982%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Inguinal hernia07.16.02.0010.014982%Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease10.02.01.033; 22.01.02.0030.059928%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.022473%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Lactase deficiency14.02.02.003; 07.17.01.006--Not Available
Lactic acidosis14.01.01.002--Not Available
Lactose intolerance14.02.02.001; 07.17.01.003--Not Available
Lenticular opacities06.06.01.0030.014982%Not Available
Leukopenia01.02.02.0010.014982%Not Available
Liver disorder09.01.08.0010.067419%Not Available
Liver function test abnormal13.03.01.0130.014982%Not Available
Lung disorder22.02.07.0010.014982%Not Available
Lymphoma16.20.01.001; 01.12.01.0010.009771%Not Available
Macular oedema06.04.06.0050.014982%Not Available
Malaise08.01.01.003--
Muscle spasms15.05.03.004--
Myalgia15.05.02.0010.052437%
Myocardial infarction24.04.04.009; 02.02.02.007--
Myopathy15.05.05.0010.014982%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.014982%
Neoplasm16.16.02.0010.003908%Not Available
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