Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxycycline hyclate
Drug ID BADD_D00727
Description Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code A01AB22; J01AA02
DrugBank ID DB00254
KEGG ID D02129
MeSH ID D004318
PubChem ID 54705095
TTD Drug ID D0S0LZ
NDC Product Code 68999-984; 46708-353; 62332-387; 68308-715; 29033-053; 46708-482; 50090-2446; 68999-626; 16110-501; 70518-3135; 68308-710; 71205-156; 70518-3039; 0591-4575; 62332-362; 0395-8059; 51862-559; 63187-818; 46708-352; 53489-119; 45865-116; 68788-9037; 51862-557; 68999-625; 50090-5588; 68382-709; 70518-3363; 59929-344; 0591-6125; 0143-3142; 46708-484; 0143-9802; 24658-312; 71057-3440; 23155-141; 55700-470; 11014-0090; 71610-087; 68071-4836; 72578-054; 61919-907; 51473-0501; 38779-0434; 63629-6880; 71335-1549; 0143-2112; 62332-482; 71335-1182; 71610-117; 23155-142; 55018-151; 50090-4981; 0904-0428; 63187-845; 55488-0100; 72189-052; 62332-483; 53002-2711; 46708-388; 68308-775; 0527-1336; 0904-0430; 68071-3104; 62135-625; 10695-103; 68788-7638; 70518-3213; 60760-626; 27241-140; 50090-0023; 71335-1768; 68382-708; 46708-499; 51927-3129; 62135-984; 50268-279; 60505-4382; 71335-1316; 69434-017; 72336-596; 50090-3860; 68382-221; 60592-201; 50090-3924; 72143-211; 0591-4550; 62135-626; 23155-143; 43063-604; 72578-001; 51862-695; 63629-8262; 70518-1627; 62332-388; 70518-3214; 67296-1811; 62332-499; 51862-696; 63629-7921; 67296-0329; 0591-5553; 68071-4950; 47781-491; 60505-4384; 11014-0235; 50090-3037; 67296-1431; 0143-3141; 67296-1801; 69489-111; 43547-462; 62332-352; 55154-7128; 61919-667; 62332-353; 68071-3252; 46708-362; 16110-502; 62135-596; 50090-3859; 55289-502; 51927-0130; 51862-709; 67698-101; 68382-222; 46708-483; 16110-601; 63629-7961; 60687-513; 55154-8079; 62332-481; 50090-5560; 55289-866; 70771-1587; 42582-216; 72578-055; 63629-6371; 69434-016; 43063-019; 63629-1531; 63187-942; 27241-153; 71335-1686; 53489-647; 45865-444; 51862-562; 42806-312; 72189-127; 80425-0114; 49452-2694; 53489-120; 70934-810; 46708-387; 42806-362; 70771-1359; 63739-168; 51862-558; 68047-714; 43386-794; 67296-1743; 68071-5067; 69668-515; 68382-710; 62584-693; 70771-1104; 71205-554; 27808-234; 68071-5265; 50090-3783; 42582-215; 50090-5825; 71205-653; 63629-7178; 51862-571; 70934-625; 27241-154; 50090-3744; 50090-4867; 62991-2572; 40032-794; 43547-324; 70771-1358; 50090-5380; 68999-985; 62135-985; 68071-5259; 50268-278; 46708-363; 71205-518; 70771-1588; 51407-298; 43063-988; 27241-141; 53489-118; 70771-1589; 68308-716; 70518-1248; 46708-481; 60429-069; 23155-611; 42192-501; 29033-052; 76420-044; 68788-7474; 51552-0852; 0591-6100; 43547-325; 68071-4883; 68071-3386; 60760-215; 55289-107; 50909-8105; 50090-0026; 0069-0950; 55700-732; 62332-363; 0143-9803; 68788-7371; 67405-550; 71052-030; 68071-5232; 50090-3218; 43063-999; 62332-484; 71335-1464; 47621-018; 50268-277; 69263-501; 11014-0091
Synonyms Doxycycline | Doxycycline Monohydrate | Vibramycin | Atridox | Doxycycline Phosphate (1:1) | BMY-28689 | BMY 28689 | BMY28689 | BU-3839T | BU 3839T | BU3839T | Doryx | Doxycycline Calcium Salt (1:2) | Doxycycline Hyclate | Doxycycline Hemiethanolate | Doxycycline Monohydrochloride, 6-epimer | Doxycycline Monohydrochloride, 6 epimer | Doxycycline Monohydrochloride, Dihydrate | Doxycycline Calcium | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- | Alpha-6-Deoxyoxytetracycline | Alpha 6 Deoxyoxytetracycline | Doxycycline-Chinoin | Doxycycline Chinoin | Hydramycin | Oracea | Periostat | Vibra-Tabs | Vibra Tabs | Vibramycin Novum | Vibravenos
Chemical Information
Molecular Formula C24H33ClN2O10
CAS Registry Number 24390-14-5
SMILES CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.003--Not Available
Pericarditis02.06.02.001--
Periodontitis11.01.04.012; 07.09.01.002--Not Available
Photosensitivity reaction23.03.09.003--
Premenstrual syndrome21.01.01.007; 19.04.02.009--Not Available
Pulpitis dental07.09.12.001; 11.01.04.009--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Rash maculo-papular23.03.13.004--
Rhinitis22.07.03.006; 11.01.13.004--
Sensitivity of teeth07.09.06.003--Not Available
Serum sickness12.02.08.004; 10.01.03.004--
Sinus congestion22.04.06.001--Not Available
Sinus headache22.02.05.023; 17.14.01.002--
Sinusitis22.07.03.007; 11.01.13.005--
Skin infection23.09.04.002; 11.01.12.003--
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Swelling08.01.03.015--Not Available
Systemic lupus erythematosus23.03.02.006; 15.06.02.003; 10.04.03.004--Not Available
Tenderness08.01.08.005--Not Available
Tension19.06.02.005--Not Available
Tension headache17.14.01.004--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tooth abscess07.09.01.003; 11.01.04.003--Not Available
Tooth disorder07.09.05.001--Not Available
Tooth injury12.01.09.004; 07.09.05.003--Not Available
Tooth loss07.09.09.001--Not Available
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