Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxycycline hyclate
Drug ID BADD_D00727
Description Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code A01AB22; J01AA02
DrugBank ID DB00254
KEGG ID D02129
MeSH ID D004318
PubChem ID 54705095
TTD Drug ID D0S0LZ
NDC Product Code 68999-984; 46708-353; 62332-387; 68308-715; 29033-053; 46708-482; 50090-2446; 68999-626; 16110-501; 70518-3135; 68308-710; 71205-156; 70518-3039; 0591-4575; 62332-362; 0395-8059; 51862-559; 63187-818; 46708-352; 53489-119; 45865-116; 68788-9037; 51862-557; 68999-625; 50090-5588; 68382-709; 70518-3363; 59929-344; 0591-6125; 0143-3142; 46708-484; 0143-9802; 24658-312; 71057-3440; 23155-141; 55700-470; 11014-0090; 71610-087; 68071-4836; 72578-054; 61919-907; 51473-0501; 38779-0434; 63629-6880; 71335-1549; 0143-2112; 62332-482; 71335-1182; 71610-117; 23155-142; 55018-151; 50090-4981; 0904-0428; 63187-845; 55488-0100; 72189-052; 62332-483; 53002-2711; 46708-388; 68308-775; 0527-1336; 0904-0430; 68071-3104; 62135-625; 10695-103; 68788-7638; 70518-3213; 60760-626; 27241-140; 50090-0023; 71335-1768; 68382-708; 46708-499; 51927-3129; 62135-984; 50268-279; 60505-4382; 71335-1316; 69434-017; 72336-596; 50090-3860; 68382-221; 60592-201; 50090-3924; 72143-211; 0591-4550; 62135-626; 23155-143; 43063-604; 72578-001; 51862-695; 63629-8262; 70518-1627; 62332-388; 70518-3214; 67296-1811; 62332-499; 51862-696; 63629-7921; 67296-0329; 0591-5553; 68071-4950; 47781-491; 60505-4384; 11014-0235; 50090-3037; 67296-1431; 0143-3141; 67296-1801; 69489-111; 43547-462; 62332-352; 55154-7128; 61919-667; 62332-353; 68071-3252; 46708-362; 16110-502; 62135-596; 50090-3859; 55289-502; 51927-0130; 51862-709; 67698-101; 68382-222; 46708-483; 16110-601; 63629-7961; 60687-513; 55154-8079; 62332-481; 50090-5560; 55289-866; 70771-1587; 42582-216; 72578-055; 63629-6371; 69434-016; 43063-019; 63629-1531; 63187-942; 27241-153; 71335-1686; 53489-647; 45865-444; 51862-562; 42806-312; 72189-127; 80425-0114; 49452-2694; 53489-120; 70934-810; 46708-387; 42806-362; 70771-1359; 63739-168; 51862-558; 68047-714; 43386-794; 67296-1743; 68071-5067; 69668-515; 68382-710; 62584-693; 70771-1104; 71205-554; 27808-234; 68071-5265; 50090-3783; 42582-215; 50090-5825; 71205-653; 63629-7178; 51862-571; 70934-625; 27241-154; 50090-3744; 50090-4867; 62991-2572; 40032-794; 43547-324; 70771-1358; 50090-5380; 68999-985; 62135-985; 68071-5259; 50268-278; 46708-363; 71205-518; 70771-1588; 51407-298; 43063-988; 27241-141; 53489-118; 70771-1589; 68308-716; 70518-1248; 46708-481; 60429-069; 23155-611; 42192-501; 29033-052; 76420-044; 68788-7474; 51552-0852; 0591-6100; 43547-325; 68071-4883; 68071-3386; 60760-215; 55289-107; 50909-8105; 50090-0026; 0069-0950; 55700-732; 62332-363; 0143-9803; 68788-7371; 67405-550; 71052-030; 68071-5232; 50090-3218; 43063-999; 62332-484; 71335-1464; 47621-018; 50268-277; 69263-501; 11014-0091
Synonyms Doxycycline | Doxycycline Monohydrate | Vibramycin | Atridox | Doxycycline Phosphate (1:1) | BMY-28689 | BMY 28689 | BMY28689 | BU-3839T | BU 3839T | BU3839T | Doryx | Doxycycline Calcium Salt (1:2) | Doxycycline Hyclate | Doxycycline Hemiethanolate | Doxycycline Monohydrochloride, 6-epimer | Doxycycline Monohydrochloride, 6 epimer | Doxycycline Monohydrochloride, Dihydrate | Doxycycline Calcium | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- | Alpha-6-Deoxyoxytetracycline | Alpha 6 Deoxyoxytetracycline | Doxycycline-Chinoin | Doxycycline Chinoin | Hydramycin | Oracea | Periostat | Vibra-Tabs | Vibra Tabs | Vibramycin Novum | Vibravenos
Chemical Information
Molecular Formula C24H33ClN2O10
CAS Registry Number 24390-14-5
SMILES CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Essential hypertension24.08.02.008--Not Available
Fistula15.03.02.001--Not Available
Fontanelle bulging18.04.04.001; 17.02.05.006--Not Available
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Gingival pain07.09.04.001--
Gingival swelling07.05.04.003--Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glossitis07.14.01.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hepatotoxicity09.01.07.009; 12.03.01.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Menorrhagia21.01.03.002--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.004--Not Available
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
Oral pain07.05.03.002--
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