Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxycycline
Drug ID BADD_D00725
Description Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code A01AB22; J01AA02
DrugBank ID DB00254
KEGG ID D00307
MeSH ID D004318
PubChem ID 54671203
TTD Drug ID D0S0LZ
NDC Product Code 63629-8212; 71205-616; 65841-823; 23155-133; 70934-085; 65841-822; 43063-985; 72789-199; 27808-233; 70934-178; 71335-0823; 50090-4833; 43063-886; 68180-657; 0713-0554; 40032-790; 67296-1368; 42291-156; 0713-0572; 55700-122; 43386-790; 68382-706; 50909-8106; 60219-1100; 67457-437; 0527-1535; 46708-249; 68180-651; 0527-1335; 70710-1124; 68084-743; 0299-3822; 55018-164; 53002-0673; 70710-1123; 67296-1385; 70771-1006; 0527-1338; 63304-615; 71610-220; 11014-0092; 49884-726; 50268-281; 61919-474; 70771-1008; 70518-0213; 68999-417; 40032-792; 70934-808; 50090-4592; 60687-344; 70710-1122; 0713-0571; 63304-130; 46708-250; 51407-387; 49884-727; 63187-672; 43386-791; 68180-652; 68382-782; 63629-2183; 0713-0570; 70518-3365; 69097-228; 63304-616; 68382-707; 63629-7751; 72189-006; 62135-417; 62332-249; 50090-1787; 63323-130; 67296-1762; 70771-1007; 67296-1025; 70710-1121; 63304-614; 70934-325; 52584-437; 63304-132; 0713-0555; 0404-9855; 62332-250; 66993-815; 23155-136; 43386-792; 65841-821; 55488-0200; 63187-936; 23155-135; 69238-1100; 49884-305; 0069-0970; 47621-017; 67296-1570; 68382-911; 50268-280; 71335-1988; 50090-3809; 50090-4599; 68071-2617; 72789-047; 67296-1688; 71335-1479; 40032-791; 63187-712; 71205-135; 63187-135; 69238-1500; 63304-173; 70771-1121; 68382-910; 0527-1537; 71335-0436; 50090-1472; 61919-433; 68071-4354; 69988-0020; 70771-1122; 71335-0861; 54348-573; 67296-1674; 0115-1327; 53002-0671; 61919-276; 55700-723; 53002-0672; 59929-631; 63629-7970; 70518-0187; 23155-134; 69238-1501; 70771-1009; 71205-385; 63304-131; 0143-9381; 68180-650; 70934-499
Synonyms Doxycycline | Doxycycline Monohydrate | Vibramycin | Atridox | Doxycycline Phosphate (1:1) | BMY-28689 | BMY 28689 | BMY28689 | BU-3839T | BU 3839T | BU3839T | Doryx | Doxycycline Calcium Salt (1:2) | Doxycycline Hyclate | Doxycycline Hemiethanolate | Doxycycline Monohydrochloride, 6-epimer | Doxycycline Monohydrochloride, 6 epimer | Doxycycline Monohydrochloride, Dihydrate | Doxycycline Calcium | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- | Alpha-6-Deoxyoxytetracycline | Alpha 6 Deoxyoxytetracycline | Doxycycline-Chinoin | Doxycycline Chinoin | Hydramycin | Oracea | Periostat | Vibra-Tabs | Vibra Tabs | Vibramycin Novum | Vibravenos
Chemical Information
Molecular Formula C22H24N2O8
CAS Registry Number 564-25-0
SMILES CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myalgia15.05.02.001--
Nail discolouration23.02.05.001--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.000892%
Neck pain15.03.04.009--
Nephropathy toxic12.03.01.010; 20.05.03.002--Not Available
Neutropenia01.02.03.004--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophageal ulcer07.04.05.0020.000157%
Oesophagitis07.08.05.0010.000105%
Oral pain07.05.03.002--
Pain08.01.08.004--
Pain in jaw15.02.01.003--Not Available
Pancreatitis07.18.01.0010.000105%
Pancreatitis acute07.18.01.0020.000105%Not Available
Panic attack19.06.04.0010.000105%Not Available
Paraesthesia17.02.06.0050.000157%
Pericarditis02.06.02.001--
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Phlebitis24.05.03.001; 12.02.01.002--
Photoonycholysis23.02.05.021--Not Available
Photosensitivity reaction23.03.09.003--
Platelet count decreased13.01.04.0010.000105%
Premenstrual syndrome21.01.01.007; 19.04.02.009--Not Available
Proctitis07.08.04.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pulpitis dental07.09.12.001; 11.01.04.009--Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.0010.000367%Not Available
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